Comparing absorbable and non-absorbable sutures in lung cancer surgery

Comparison of Clinical Effects of Absorbable and Non-absorbable Suture in Bronchial Sleeve Resection

This study is testing whether absorbable or non-absorbable sutures are better for reducing complications in lung cancer surgery for patients with centrally located tumors.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 40 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: The Affiliated Hospital of Qingdao University (Academic / other)
• Locations: 1 site (Qingdao, Shandong)
• Trial ID: NCT06344962 on ClinicalTrials.gov

What this trial studies

This study investigates the clinical effects of absorbable versus non-absorbable sutures during bronchial sleeve resection, a surgical procedure for lung cancer patients with centrally located tumors. The research aims to determine which type of suture leads to fewer complications during the anastomosis process, which is known to be complex and challenging. A total of 40 patients will be enrolled, with 20 receiving absorbable sutures and 20 receiving non-absorbable sutures. The primary endpoint is the incidence rate of anastomotic complications following the surgery.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 with non-small cell lung cancer located near the bronchus and adequate organ function for surgery.

Not a fit: Patients with significant medical conditions or psychiatric diseases that may affect compliance or surgical tolerance will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved surgical outcomes and reduced complications for lung cancer patients undergoing bronchial sleeve resection.

How similar studies have performed: There are few studies comparing absorbable and non-absorbable sutures in this specific surgical context, making this approach relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Age 18 to 75 years old.
2. The tumor is located in the opening of bronchus, or the edge of the tumor is less than 2 cm away from the opening of the bronchi, while the distance between the edge of the tumor and the carina is more than 1.5 cm.
3. Patients with pathological diagnosis of non-small cell lung cancer.
4. No distant metastasis in preoperative clinical evaluation.
5. Adequate cardiac function, pulmonary function, liver function and renal function for anesthesia and bronchial sleeve resection.
6. American Society of Anesthesiologists (ASA) score: Grade I-III.
7. Patients who can coordinate the treatment and research and sign the informed consent.

Exclusion Criteria:

1. Patients with a significant medical condition which is thought unlikely to tolerate the surgery or unsuitable for this study after the evaluation of the investigator.
2. Patients with psychiatric disease who are expected lack of compliance with the protocol.

Where this trial is running

Qingdao, Shandong

• the Affiliated Hospital of Qingdao University — Qingdao, Shandong, China (Recruiting)

Study contacts

• Principal investigator: Wenjie Jiao, PhD — The Affiliated Hospital of Qingdao University
• Study coordinator: Zhe Wu, PhD

Conditions Suture, Complication; Suture; Bronchial Sleeve Resection; Central Primary Lung Cancer; Non-Small Cell Lung Cancer