Comparing 7-day and 14-day doxycycline treatment for multiple erythema migrans
Duration of Doxycycline Treatment in Patients With Multiple Erythema Migrans (MEM). A Randomized Clinical Trial
NA · University Medical Centre Ljubljana · NCT03337932
This study is testing whether a 7-day or a 14-day course of doxycycline works better for people with multiple erythema migrans.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Medical Centre Ljubljana (other) |
| Locations | 1 site (Ljubljana) |
| Trial ID | NCT03337932 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of two different durations of doxycycline treatment, specifically 7 days versus 14 days, in patients diagnosed with multiple erythema migrans. Participants will receive doxycycline 100 mg orally twice daily for the assigned duration, while controls will not have a history of Lyme disease. The goal is to determine which treatment duration is more effective in managing this condition.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with multiple erythema migrans.
Not a fit: Patients who are pregnant, lactating, immunocompromised, or have serious adverse reactions to doxycycline will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide clearer guidelines for the optimal duration of doxycycline treatment, improving patient outcomes in managing erythema migrans.
How similar studies have performed: While there have been studies on doxycycline for Lyme disease, this specific comparison of treatment duration is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • multiple erythema migrans Exclusion Criteria: * pregnancy or lactation * immunocompromised * serious adverse event to doxycycline * taking antibiotic with antiborrelial activity within 10 days * extracutaneous manifestations of lyme borreliosis
Where this trial is running
Ljubljana
- University Medical center Ljubljana — Ljubljana, Slovenia (RECRUITING)
Study contacts
- Principal investigator: Daša Stupica, MD PhD — University Medical Centre Ljubljana
- Study coordinator: Daša Stupica, MD, PhD
- Email: dasa.stupica@kclj.si
- Phone: +386 31 689 324
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Erythema Chronicum Migrans