Comparative analysis of Alzheimer's and multi-infarct dementia
Comparative Study Between Alzheimer's and Multi-infarct Dementia Regarding to Clinical Aspect, Biomarker, and Cortical Excitability
This study is trying to see if certain blood and spinal fluid markers can help tell the difference between Alzheimer's and multi-infarct dementia to improve how we diagnose and manage these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 76 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | All |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Assiut) |
| Trial ID | NCT05781139 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare Alzheimer's disease with multi-infarct dementia by identifying and analyzing biomarkers that can help in diagnosing and tracking disease progression. It focuses on noninvasive and cost-effective methods to measure neurofilament light (NfL) levels in serum, as well as other biomarkers like CHI3L1 and CXCL13 in cerebrospinal fluid (CSF). The study will also utilize transcranial magnetic stimulation (TMS) to assess cortical properties related to dementia. By understanding these biomarkers, the study seeks to improve diagnostic accuracy and patient management in dementia care.
Who should consider this trial
Good fit: Ideal candidates for this study are men and women aged 50 to 80 who are reliable in providing individual data.
Not a fit: Patients with other neurological or psychiatric disorders, severe motor disabilities, or those outside the age range may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better diagnostic tools and treatment strategies for patients with dementia.
How similar studies have performed: Other studies have shown promise in using biomarkers for dementia diagnosis, but this specific comparative approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Men or women of at least 50-80 years of age. 2. Are reliable in individual data and willing to make themselves available for the duration of the study 3. Clear written informed consent obtained from 1st degree of relative from each patient participant and control himself in the trial. Exclusion Criteria: 1. age below 50 years and above 80 years. 2. other neurological disorders or psychiatric disorders; previous history of stroke; metabolic disturbance; other major medical illnesses; epilepsy; inflammatory, autoimmune, or infectious disease; metallic objects in the body; craniotomy in the past. 3. Presence of clinically significant medical or psychiatric condition that may increase the risk associated with the study 4. Participation in any other type of medical research that may interfere with the interpretation of the study. 5. Patients with severe motor disability (bed-ridden) that may interfere with the study procedure. 6. Patients with history of seizures or epilepsy including history in a first degree relative
Where this trial is running
Assiut
- Medicine — Assiut, Egypt (Recruiting)
Study contacts
- Study coordinator: Esraa A Abdelregal, Ass lecturer
- Email: esraa161292@gmail.com
- Phone: 00201033400846
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.