Communicating future heart-attack risk to people sent home after emergency chest pain

Developing a Brief Intervention to Communicate Cardiovascular Risk to Patients Presenting to the Emergency Department With Chest Pain: a Co-Production Approach. Phase 2.

Not applicable Interventional University of Edinburgh · NCT06903442

This project will try giving adults who came to the emergency department with chest pain (but no heart attack) their troponin result plus a short, co-designed conversation about heart risk to see if that improves their understanding and follow-up.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment118 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Edinburgh Academic / other
Locations1 site (Edinburgh)
Trial IDNCT06903442 on ClinicalTrials.gov

What this trial studies

The trial delivers a brief, co-designed cardiovascular intervention in people who present to the emergency department with chest pain but do not have an acute heart attack. Participants with a modestly raised high-sensitivity troponin I (between 5 ng/L and the sex-specific 99th centile) and at least one modifiable risk factor will receive their troponin value and a short structured conversation about future heart risk. The intervention was co-produced with patients and is delivered outpatient after the index visit. The phase 2 work focuses on testing the acceptability and feasibility of delivering this brief risk-communication in an ED-linked pathway.

Who should consider this trial

Good fit: Adults (18+) living in Scotland who come to the ED with symptoms suggesting acute coronary syndrome, have a troponin I 5 ng/L up to the sex-specific 99th centile, no prior cardiovascular disease, at least one modifiable risk factor, can speak English, and can attend outpatient follow-up are suitable.

Not a fit: People diagnosed with acute coronary syndrome during the visit, those with existing cardiovascular disease, those unable to consent or attend outpatient sessions, non-English speakers, or those already undergoing cardiac investigations are not likely to benefit from this intervention.

Why it matters

Potential benefit: If successful, this approach could help patients better understand their future heart-attack risk and prompt earlier risk-reducing actions or follow-up.

How similar studies have performed: Brief, personalized risk-communication approaches have shown promise in other clinical settings, but delivering troponin-based brief interventions after ED chest pain is relatively new.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients who present to the Emergency Department with symptoms suggestive of acute coronary syndrome
* A maximum high-sensitivity cardiac troponin I between 5 ng/L and the sex-specific 99th centile.
* Resides in Scotland and has a CHI number
* Adults aged 18 and over
* No history of cardiovascular disease
* At least 1 modifiable cardiovascular risk factor: current smoker, hypertension (140/90 mmHg), hypercholesterolaemia (\>6.0 mmol/L), overweight and obesity (BMI \>25), hyperglycaemia or diabetes mellitus.
* Patients who are able to provide informed consent

Exclusion Criteria:

* Patients with a diagnosis of acute coronary syndrome during index presentation
* Patients who are not able to give informed consent
* Patients who do not speak English
* Patients who are unable to attend hospital as outpatient to receive the cardiovascular brief intervention
* Patients with ongoing or planned cardiovascular investigations or interventions
* Patients with chronic kidney disease and a eGFR below 30 ml/min

Where this trial is running

Edinburgh

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Cardiovascular Diseases
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.