Combining VIC-1911 with Osimertinib for advanced lung cancer

Phase I Clinical Study of VIC-1911 Combined With Osimertinib in the Treatment of Advanced Non-small Cell Lung Cancer With EGRF- Mutation

This study is testing a new combination of two drugs, VIC-1911 and Osimertinib, to see if it can help people with advanced lung cancer that has certain genetic changes.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 72 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Jiesi Yingda Pharmaceutical Technology (Suzhou) Co., Ltd. (Academic / other)
• Drugs / interventions: osimertinib, chemotherapy, immunotherapy, oxitinib
• Locations: 1 site (Guangdong)
• Trial ID: NCT05489731 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the safety and effectiveness of VIC-1911, an Aurora A inhibitor, in combination with Osimertinib for patients with advanced non-small cell lung cancer (NSCLC) that has specific EGFR mutations. It is a nonrandomized, open-label phase I study that includes a dose escalation and extension phase to determine the optimal dosage and monitor pharmacokinetics. Patients will undergo safety assessments, imaging examinations, and efficacy evaluations throughout the treatment period. The study aims to provide insights into the tolerability and preliminary antitumor efficacy of this combination therapy.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-75 with advanced EGFR mutation-positive NSCLC who have previously failed other treatments.

Not a fit: Patients with NSCLC who do not have the specified EGFR mutations or those who have not previously undergone EGFR-TKI treatment may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could offer a new therapeutic option for patients with advanced EGFR-mutant NSCLC.

How similar studies have performed: Other studies have shown promise in targeting EGFR mutations in NSCLC, suggesting potential for success with this combination approach.

Eligibility criteria

Inclusion Criteria:

1. Voluntarily participate in clinical research, sign written informed consent, and be able to abide by clinical visits and research Relevant procedures;
2. Male or female patients aged 18-75 (including boundary value) when signing the informed consent form;
3. NSCLC with advanced EGFR mutation positive \[exon 19 deletion (19del) and exon 21 L858R (21l858r) point mutation\] confirmed by cytology or histology A. only applicable to the dose increasing stage: after receiving the first / second generation EGFR-TKI treatment failure T790M mutation negative or third-generation EGFR-TKI treatment failed, and then received platinum containing dual drug chemotherapy Terminal NSCLC patients after failure; B. only applicable to the expansion phase: (1) queue 1: after the treatment failure of the first / second generation EGFR-TKI NSCLC patients with T790M mutation positive; (2) Cohort 2: NSCLC patients who failed to receive three generations of EGFR-tki treatment;
4. According to RECIST 1.1 standard, patients must have a passing shadow Measurable lesions assessed by imaging examination;
5. The EC0G score is 0 or 1;
6. Estimated survival time ≥ 3 months;
7. Bone marrow reserve and organ function level within 7 days before administration must meet the following requirements:

   1. Bone marrow reserve: hemoglobin (HB) ≥ 9.0 g/dl, absolute neutrophil count （ANC）≥ 1.5 × 109/l, platelet (PLT) ≥ 100 × 109/l, opened during the study treatment period Blood transfusion (whole blood, platelets or red blood cells) is prohibited 1 month before the start;
   2. Coagulation function: international normalized ratio (INR) ≤ 1.5 × Upper normal value (ULN), active Partial prothrombin time (APTT) ≤ 1.5 × ULN；
   3. Liver function: aspartate aminotransferase (AST) and alanine in the absence of liver metastasis Transaminase (ALT) ≤ 2.5 × ULN； In case of liver metastasis, AST and alt ≤ 5.0 × ULN；Total bilirubin in serum (TBIL) ≤ 1.5 × ULN (patients known to have Gilbert syndrome Only when total bilirubin ≤ 3 × ULN, direct bilirubin ≤ 1.5 × In the case of ULN, it will be Consider);
   4. Renal function: creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 40 ml/min (according to Cockcroft-Gault formula);
   5. Cardiac function: left ventricular ejection fraction (LVEF) ≥ 50%; ECG is basically normal,QT interval (QTCF) corrected by fridericia formula: male ≤ 450 ms, female ≤ 470 ms；
8. Qualified patients (male and female) with fertility must agree to give drugs during the trial or at the end of the trial Use reliable contraceptive methods (hormone or barrier method or abstinence) with their partners for at least 6 months Etc.); Women of childbearing age (refer to the appendix of the text for the definition) within 7 days before the first use of the investigational drug The pregnancy test must be negative.

Exclusion criteria：

1. Known allergy to, or hypersensitivity to, VIC-1911, osimertinib, or any of the excipient ingredients
2. Subject has previously discontinued osimertinib due to toxicity or other safety events Interstitial lung disease/non-infectious pneumonia; Symptoms or signs of severe arrhythmia with prolonged QTc interval; Symptomatic congestive heart failure
3. Other side effects caused by previous treatment did not alleviate to CTCAE≤ grade 1, alopecia or otherwise
4. A history of ocular disease was present, and the patient had occlusion of central or branch retinal arteries or veins with visual acuity Significant decline, or a history of visual impairment due to other retinal diseases as determined by an ophthalmologist or Performance
5. The following infectious diseases are known to be active, such as:

   Human immunodeficiency virus antibody (HIV-AB) positive; Hepatitis B surface antigen (HBsAg) positive and HBV-DNA exceeding the upper limit of normal value; Hepatitis C virus antibody (HCV-AB) positive and HCV RNA positive
6. Other active infections requiring intravenous antibiotics within 7 days before administration;
7. Use of potent CYP inducer 28 days before administration or within 5 half-lives of the drug, whichever is longer A guide or inhibitor;
8. Had undergone a major surgical procedure within 28 days prior to drug administration or was expected to require a major procedure during the trial Surgery;
9. Received the latest antitumor therapy (chemotherapy, targeted therapy, radiotherapy, immunotherapy, biological therapy) Therapy or endocrine therapy), less than 5 half-lives after or after the first administration of the drug Less than 28 days (whichever is longer). Had received the drug within 14 days before the first dose with definite resistance The effect of traditional Chinese medicine on tumor;
10. A history of serious cardiovascular and cerebrovascular diseases, including but not limited to:

    uncontrolled hypertension (systolic blood pressure \>160 mmHg or shu) after standard clinical treatment Tension \>100 mmHg for more than 4 weeks); I have severe cardiac rhythm or conduction abnormalities, such as ventricular arrhythmias that require clinical intervention, Degree II-III atrioventricular block, etc Patients with grade III-IV cardiac insufficiency according to New York Heart Association (NYHA) criteria Any arterial thromboembolic event, including but not limited to myocardial infarction, occurred within 6 months prior to dosing Plug, transient ischemic attack, unstable angina pectoris or other grade 3 or above cardiovascular and cerebrovascular disease Events; Any factor that increases the risk of prolonged QTc intervals or arrhythmias: e.g., heart failure, hypokalemia Haemaemia, congenital long QT syndrome, or the use of anything known to prolong the QT interval Concomitant drugs (see Appendix of the main text for details), except antibiotics used to prevent or treat infection;
11. Parenchymal or meningeal metastases with clinical symptoms were not eligible for inclusion as judged by the investigator. Such as Previous systemic and radical brain metastases therapy (radiotherapy or surgery) proved stable on imaging It has been maintained for at least 28 days and has stopped systemic hormone therapy for more than 14 days without clinical symptoms Is allowed to enter the group;
12. Suffers from hematological malignancies;
13. Other malignant tumors have been diagnosed within 5 years before the first use of the study drug; Effectively treated skin Basal cell carcinoma, squamous cell carcinoma of the skin, and/or effectively resected cervical cancer in situ and/or breast Except the cancer;
14. Inability to swallow medication;
15. Gastrointestinal diseases that may affect the absorption or tolerability of the trial drug, such as refractory or screening CTCAE\> grade 2 gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea, etc.);
16. Patients with difficulty in venous blood collection;
17. Women who have a positive pregnancy test or are breastfeeding during the screening period;
18. Administration of an investigational drug that has undergone clinical trials of other drugs within 28 days prior to administration;
19. Previous treatment with other Aurora kinase inhibitors;
20. Patients with a history of blood donation or blood loss of more than 400 mL 3 months before screening;
21. Anything else that, in the opinion of the investigator, may affect the subject to provide informed consent or follow the protocol Circumstances, or the subject's participation in the trial may affect the results of the trial or their own safety.

Where this trial is running

Guangdong

• Zhangli — Guangdong, China (Recruiting)

Study contacts

• Study coordinator: li zhang, professor

Conditions Advanced Non-small Cell Lung Cancer