Combining surufatinib with gemcitabine and nab-paclitaxel for pancreatic cancer treatment

Efficacy and Safety of Surufatinib Combined With Gemcitabine and Albumin-bound Paclitaxel in the Peri-operative Treatment of Locally Advanced or Borderline Resectable Pancreatic Cancer: An Exploratory Study

This study is testing if a new combination of medications can help people with locally advanced or borderline resectable pancreatic cancer before surgery.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 29 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Tianjin Medical University Cancer Institute and Hospital (Academic / other)
• Drugs / interventions: surufatinib
• Locations: 1 site (Tianjin, Tianjin)
• Trial ID: NCT05908747 on ClinicalTrials.gov

What this trial studies

This phase II, multi-centered, open-label study investigates the efficacy and safety of surufatinib combined with gemcitabine and nab-paclitaxel as a peri-operative treatment for patients with locally advanced or borderline resectable pancreatic cancer. Participants will receive surufatinib orally once daily, while gemcitabine and nab-paclitaxel will be administered intravenously on specified days of a 28-day cycle. The study also aims to explore potential therapeutic biomarkers to better understand treatment responses.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-75 with histologically confirmed high-risk resectable or borderline resectable pancreatic cancer and no BRCA1/2 or PALB2 mutations.

Not a fit: Patients with distant metastasis or those who have previously received systemic treatment or radiotherapy may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment approach could improve outcomes for patients with high-risk pancreatic cancer by enhancing the effectiveness of peri-operative therapy.

How similar studies have performed: While this specific combination is novel, similar approaches in treating pancreatic cancer have shown promise in other studies.

Eligibility criteria

Inclusion Criteria:

* Histologically or cytologically confirmed high-risk resectable or borderline resectable pancreatic cancer;
* 18-75 years old (including 18 and 75 years old);
* No BRCA1/2 or PALB2 mutation;
* No previous systematic treatment or radiotherapy;
* Eastern Cooperation Oncology Group (ECOG) performance status of 0-1;
* Life expectancy ≥ 6 months;
* At least one measurable lesion according to RECIST version 1.1;
* Adequate organ and bone marrow functions: -Absolute neutrophil count≥1.5x10\^9/L; -Platelet count≥100x10\^9/L; -Hemoglobin≥9g/dL; -Serum bilirubin≤1.5x the upper limit of normal (ULN); -Alanine aminotransferase (ALT) and aspartate aminotransferase (AST)≤2.5x ULN; -Serum creatinine≤1.5x ULN or endogenous creatinine clearance rate ≥ 60ml / min; -INR≤1.5×ULN, PT and APTT≤1.5×ULN；
* Women of childbearing age need to take effective contraceptive measures.

Exclusion Criteria:

* With distant metastasis;
* Have received blood transfusion treatment, blood products and hematopoietic factors, such as albumin and granulocyte colony-stimulating factor (G-CSF) within 14 days before enrollment;
* Have received any surgery or invasive treatment or operation within 4 weeks before enrollment (except venous catheterization, puncture and drainage, etc.);
* Allergic to the study drug or any of its adjuvants;
* researchers judged clinically significant electrolyte abnormalities;
* History of serious cardiovascular and cerebrovascular diseases: -Cerebrovascular accident (excluding lacunar cerebral infarction, minor cerebral ischemia or transient ischemic attack), myocardial infarction, unstable angina pectoris, and poorly controlled arrhythmia (including QTc interval ≥ 450ms for male and ≥ 470ms for female) occurred within 6 months before the first administration of the study drug (QTc interval was calculated by fridericia formula); -New York Heart Association (NYHA) cardiac function classification \> grade II or left ventricular ejection fraction (LVEF) \< 50%;
* With active ulcer, intestinal perforation and intestinal obstruction;
* Uncontrollable malignant ascites (defined as ascites that cannot be controlled by diuretics or puncture according to the judgment of the investigator);
* Clinically significant electrolyte abnormalities judged by researchers;
* With active bleeding or obvious evidence of bleeding tendency;
* Hypertension that cannot be controlled by drugs: systolic blood pressure ≥ 150 mmHg and / or diastolic blood pressure ≥ 100 mmHg;
* Women who are pregnant or lactating;
* Urinary protein ≥ ++, or the 24-hour urine protein quantification is greater than 1.0g;
* Concurrent tumors within 5 years (except treated cervical carcinoma in situ, basal cell carcinoma);
* Any disease or state that affects the absorption of drugs, or the subject cannot take oral drugs;
* Known human immunodeficiency virus (HIV) infection;
* History of clinically significant hepatic disease, including, but not limited to, known hepatitis B virus (HBV) infection with HBV DNA positive (copies ≥1×10\^4/ml or \>2000 IU/ml); known hepatitis C virus infection with HCV RNA positive (copies ≥1×10\^3/m); hepatitis and cirrhosis;
* Have any other disease, metabolic disorder, physical examination anomaly, abnormal laboratory result, or any other conditions that makes the subject not suitable for enrolling according to the judgment of the investigator.

Where this trial is running

Tianjin, Tianjin

• Tianjin Medical University Cancer Institute and Hospital — Tianjin, Tianjin, China (Recruiting)

Study contacts

• Principal investigator: Jihui Hao, M.D. — Tianjin Medical University Cancer Institute and Hospital
• Study coordinator: Jihui Hao, M.D.

Conditions Pancreatic Cancer