Combining radiation therapy with immune therapy for extensive stage lung cancer

A Randomized Controlled, Multicenter Phase II Study to Evaluate the Efficacy and Safety of Combination Therapy With Serplulimab and RT in Patients With ES-SCLC Who Have Not Progressed After Treat With Serplulimab Combined Chemotherapy

This study is testing whether adding radiation therapy to the standard treatment with Serplulimab can help people with extensive stage small cell lung cancer live longer without their cancer getting worse.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 100 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Zhejiang Cancer Hospital (other)
• Drugs / interventions: serplulimab, sulumab, Slulimab, chemotherapy, radiation, methotrexate, Cyclophosphamide, Immunotherapy
• Locations: 1 site (Hangzhou)
• Trial ID: NCT06350162 on ClinicalTrials.gov

What this trial studies

This phase II trial investigates the effects of adding radiation therapy to the standard maintenance treatment with Serplulimab in patients who have previously undergone chemotherapy for extensive stage small cell lung cancer. The study aims to determine if the combination of radiation and Serplulimab can prolong the time without cancer progression compared to using Serplulimab alone. Participants will be monitored for their response to treatment and any potential side effects. The trial includes patients aged 18 to 75 who have a confirmed diagnosis of extensive stage small cell lung cancer and meet specific eligibility criteria.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 with extensive stage small cell lung cancer who have shown a positive response to prior chemotherapy and Serplulimab.

Not a fit: Patients with prior systemic therapy for extensive stage small cell lung cancer or those with significant comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could improve survival rates and quality of life for patients with extensive stage small cell lung cancer.

How similar studies have performed: While the combination of radiation and immunotherapy is being explored, this specific approach is novel and has not been extensively tested in previous studies.

Eligibility criteria

Inclusion Criteria:

1. Voluntary participation in clinical studies; fully understand, be informed about the study and have signed the informed consent form (ICF).
2. Male or female aged ≥ 18 and ≤ 75 years, at the time of signing the ICF.
3. Willingness to follow and ability to complete all trial procedures.
4. Histologically or cytologically diagnosed with ES-SCLC (according to the Veterans Administration Lung Study Group staging system).
5. No prior systemic therapy for ES-SCLC；at the end of the combination chemotherapy with serplulimab, the efficacy evaluation is CR, PR, or SD.
6. At least one measurable lesion as assessed according to RECIST 1.1 , lesions that have received radiation therapy in the past are only considered measurable if they show clear progression.
7. An ECOG PS score of 0 or 1.
8. An expected survival ≥ 3 months.
9. Normal major organ functions
10. For participants receiving therapeutic anticoagulation: stable anticoagulant regimen
11. Negative human immunodeficiency virus (HIV) test at screening
12. Negative hepatitis B surface antigen (HBsAg) test at screening
13. Positive hepatitis B surface antibody (HBsAb) test at screening, and positive hepatitis B virus core antibody (HBcAb), no HBV-DNA test is required; or negative HBsAb at screening accompanied by either of the following: Negative total hepatitis B core antibody (HBcAb), or positive total HBcAb test followed by a negative hepatitis B virus (HBV) DNA test. The HBV DNA test will be performed only for participants who have a negative HBsAg test, a negative HBsAb test, and a positive total HBcAb test.
14. Negative hepatitis C virus (HCV) antibody test at screening, or positive HCV antibody test followed by a negative HCV RNA test at screening. The HCV RNA test will be performed only for participants who have a positive HCV antibody test.
15. For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraception.
16. For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom, and agreement to refrain from donating sperm.

Exclusion Criteria:

1. Complete response or tumor progression occurred during the combination of serplulimab and chemotherapy treatment.
2. Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases.Patients with CNS lesions treated and Asymptomatic are eligible to participate in this study if they meet all of the following criteria: Measurable lesions exist outside of CNS that meet the definition of RECISTv1.1; The patient has no history of Intracranial hemorrhage or intracerebral hemorrhage; The patient did not receive stereotactic radiotherapy within 7 days before the start of the study treatment, whole brain radiotherapy within 14 days before the start of the study treatment, or Neurosurgery resection within 28 days before the start of the study treatment; Patients do not need to continue to receive Corticosteroid treatment for CNS diseases. Allowing stable doses of anticonvulsant drugs for treatment; Transfer is limited to the cerebellum or supratentorial area (i.e. not transferred to the midbrain, pons, medulla oblongata, or spinal cord); There is no evidence to suggest progress between the completion of CNS local treatment and the initiation of study treatment; New Asymptomatic patients with central nervous system metastasis found during screening are eligible to participate in this study after receiving radiotherapy and/or surgery
3. History of leptomeningeal disease.
4. The total number of liver metastases was ≥3 or a single liver metastases was greater than 3cm
5. Uncontrolled tumor-related pain
6. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures.
7. Uncontrolled or symptomatic hypercalcemia (\> 1.5 mmol/L ionized calcium or calcium \> 12 mg/dL or corrected serum calcium \> ULN).
8. Known active or suspected autoimmune diseases. Subjects in a stable state with no need for systemic immunosuppressant therapy are allowed to enroll.
9. Have a history of Idiopathic pulmonary fibrosis, organized pneumonia (such as Bronchiolitis obliterans), drug-induced pneumonia or idiopathic pneumonia, or chest computed tomography (CT) at screening shows evidence of active pneumonia.
10. Active or latent pulmonary tuberculosis.
11. Serious cardiovascular disease (such as heart disease, myocardial infarction or cerebrovascular accident of New York Heart Association Grade II or above), unstable arrhythmia or unstable angina pectoris occurred within 3 months before the start of the study treatment.
12. Major surgical procedures other than diagnosis have been performed within 4 weeks prior to the start of the study treatment, or significant surgical procedures are expected to be required during the study period.
13. Malignant tumors other than small cell lung cancer (SCLC) occurred within 5 years before the start of the study treatment, but the cancer under study and malignant tumors with negligible risk of metastasis or death (such as the 5-year overall survival rate\>90%) were excluded, such as fully treated cervical Carcinoma in situ, non Melanoma skin cancer, localized prostate cancer, ductal carcinoma in situ or stage I Uterine cancer.
14. Severe infection occurred within 4 weeks before the start of study treatment, including but not limited to hospitalization due to infection, Bloodstream infections, severe pneumonia or any active infection that may affect the safety of patients.
15. Previously received allogeneic stem cell or solid organ transplantation.
16. Any other diseases, metabolic disorders, physical examination abnormalities, or clinical laboratory abnormalities that may affect the interpretation of results or treatment complications that may pose a high risk to patients, may result in contraindications to the use of research drugs.
17. Received attenuated live vaccines within 4 weeks prior to the start of research treatment, or expected to receive such vaccines during the treatment period of sulumab or within 5 months after the last administration of serplulimab.
18. Currently undergoing anti HBV treatment.
19. Received any other investigational drug treatment within 28 days prior to the start of the study treatment.
20. Previous treatment with CD137 agonists or immune checkpoint blockade therapy, including anti CTLA-4, anti PD-1, and anti PD-L1 therapeutic antibodies.
21. Received systemic immunostimulatory therapy (including but not limited to interferon and interleukin-2 \[IL-2\]) within 4 weeks prior to the start of study treatment or within 5 drug elimination half-lives (whichever is longer).
22. Systemic immunosuppressive drugs (including but not limited to Corticosteroid, Cyclophosphamide, Azathioprine, methotrexate, Thalidomide and anti TNF - α preparations) were used within 2 weeks before the start of the study treatment, or systemic immunosuppressive drugs were expected to be used during the study treatment, with the following exceptions: 1)Patients receiving short-term, low-dose systemic immunosuppressive drugs or patients receiving one-time pulse therapy of systemic immunosuppressive drugs (for example, receiving Corticosteroid for 48 hours to treat contrast allergy) may be qualified to participate in this study after being confirmed by the medical supervisor; 2) Patients who receive Mineralocorticoid (such as fluhydrocortisone), inhaled or low-dose Corticosteroid to treat Chronic obstructive pulmonary disease (COPD) or asthma, or low-dose Corticosteroid to treat orthostatic Hypotension or adrenal insufficiency are eligible to participate in this study.
23. Has a history of severe allergies to chimeric or humanized antibodies or fusion proteins.
24. Known hypersensitivity to serplulimab.
25. Known hypersensitivity to carboplatin or etoposide.
26. Pregnant or lactating women, or women who plan to become pregnant during the study treatment or at least 5 months after the last administration of Slulimab or 6 months after the last administration of cisplatin/carboplatin or Etoposide.
27. Researchers determine that patients cannot benefit from TRT.

Where this trial is running

Hangzhou

• Zhejiang Cancer Hospital — Hangzhou, China (RECRUITING)

Study contacts

• Principal investigator: Yun Fan, PHD — Zhejiang Cancer Hospital
• Study coordinator: Yun Fan, PHD

Conditions: Extensive Stage Lung Small Cell Cancer