Combining pulsed radiofrequency and platelet-rich plasma for treating facial pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, prospective, observational study aims to evaluate the effectiveness and safety of combining platelet-rich plasma (PRP) injections with pulsed radiofrequency (PRF) treatment for patients suffering from refractory infraorbital neuralgia (IONa). The study focuses on individuals who have not responded well to conventional therapies and are seeking a minimally invasive treatment option. Participants will be assessed for pain relief and safety outcomes, with a particular emphasis on those reluctant to undergo more destructive therapies. The study employs a propensity score matching approach to ensure balanced comparisons between treatment groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 18 to 75 years;
2. Paroxysmal or persistent stabbing pain in the distribution area of the infraorbital nerve and positive response to diagnostic block (1 ml of 2% lidocaine) prior to treatment;
3. NRS score≥7;
4. Scheduled for PRF treatment for IONa；
5. Signed informed consent.

Exclusion Criteria:

1. Platelet count \<105\*109/L, ongoing anticoagulation therapy or antiplatelets treatment, coagulation disorders or bleeding disorders;
2. Severe cardiopulmonary or hepatorenal dysfunction;
3. Infection at the puncture site; .
4. Neuralgia secondary to tissue damage around the infraorbital foramen from causes such as maxillary sinusitis or tumor;
5. History of destructive treatments such as radiofrequency thermocoagulation, chemical ablation, infraorbital neurectomy, infraorbital nerve avulsion, etc;
6. History of mental disorders；
7. History of narcotic drug abuse;
8. Unable to cooperation.

Where it's running

• Fang Luo
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Luo Fang, M.D. — Beijing Tiantan Hospital
• Study coordinator: Lu Liu, M.D.
• Email: emmaliulu@163.com
• Phone: +8618618418228

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using a patient’s own fat mixed with platelet-rich fibrin to rebuild the breast after conservation surgery

  Aiming to see if a patient’s own fat mixed with platelet-rich fibrin can help restore breast shape after breast-conserving cancer surgery.

  Recruiting The Leningrad Regional Clinical Hospital · Saint Petersburg · NCT07658170

• Platelet-Rich Plasma from Two Different Systems in Knee Osteoarthritis

  This study compares PRP made by two FDA-approved machines to see if the platelets differ and whether injections help knee symptoms.

  Recruiting Phase 4 University of California, San Francisco · San Francisco, California · NCT07491367

• PRP with fractional CO₂ laser to improve acne scars

  This will test whether adding your own platelet-rich plasma (PRP) to fractional CO₂ laser treatment can improve moderate-to-severe acne scars in adults aged 18–40.

  Recruiting Gujranwala medical college District Headquarters Hospital, Gujranwala · Gujranwala, Punjab Province · NCT07352215

• Using pulsed radiofrequency and platelet-rich plasma to treat glossopharyngeal neuralgia

  This study is testing if combining pulsed radiofrequency treatment with platelet-rich plasma can help adults with glossopharyngeal neuralgia who haven't found relief from medications.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06931457

• Combining microfracture surgery with platelet-rich plasma injection for ankle cartilage repair

  This study is testing if adding a platelet-rich plasma injection to microfracture surgery can help people with ankle cartilage damage feel better and recover more effectively.

  Recruiting Peking University Third Hospital · Beijing · NCT06358807

• Combined PRP and hyaluronic acid injections for knee osteoarthritis

  This study sees if giving a mix of platelet-rich plasma and hyaluronic acid into the knee helps people with osteoarthritis.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT05039463

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.