Combining Orelabrutinib and Obinutuzumab for Newly Diagnosed CLL/SLL

Efficacy and Safety of Orelabrutinib, Fludarabine, Cyclophosphamide, and Obinutuzumab (GA-101) (oFCG) in the Treatment of Newly Diagnosed Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL)

This study is testing a new treatment plan that combines several medications to see if it helps people with newly diagnosed Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) feel better and achieve better results.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 25 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: The First Affiliated Hospital with Nanjing Medical University (other)
• Drugs / interventions: Obinutuzumab, Orelabrutinib, immunotherapy, Cyclophosphamide, Fludarabine
• Locations: 1 site (Nanjin, Jiangsu)
• Trial ID: NCT05322733 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the safety and efficacy of a treatment regimen combining Orelabrutinib, Fludarabine, Cyclophosphamide, and Obinutuzumab in patients with newly diagnosed Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL). Participants will undergo a lead-in therapy followed by multiple cycles of the treatment, with assessments of minimal residual disease (MRD) at various stages to determine the effectiveness of the regimen. The study aims to tailor ongoing treatment based on MRD results, potentially leading to personalized therapy for patients. It is a multi-center, open-label, single-arm, non-randomized phase II trial.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 65 with a confirmed diagnosis of CD20-positive CLL/SLL who meet specific treatment initiation criteria.

Not a fit: Patients outside the age range of 18 to 65 or those with other significant health issues may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment approach could improve outcomes for patients with newly diagnosed CLL/SLL by providing a more effective and personalized therapy.

How similar studies have performed: Other studies have shown promise with similar treatment combinations, indicating potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

1. Age between 18 to 65 years old for both gender.
2. Patients have a confirmed diagnosis of CD20-positive chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL) and meet criteria to initiate first-line treatment per International Workshop on CLL Working Group (IWCLL) 2018 guidelines
3. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
4. At least one measurable disease detected by enhanced computerized tomography (CT) or magnetic resonance imaging (MRI). At least one lymph node with the longest axis \>=1.5cm and one measurable vertical dimension.
5. With life expectancy \> 6 months.
6. Patients must meet the following laboratory examination criteria during 14 days before entry:

Serum bilirubin \<1.5 Upper Limit of Normal (ULN), other than gilbert syndrome (defined as unconjugated bilirubin\>80%); Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 ULN.

Absolute neutrophil count (ANC)≥0.75×109/L and Platelets≥50×109/L (patients without exposure to G-CSF or blood transfusion within 7 days and no exposure to )

Exclusion Criteria:

1. Cumulative illness rating scale (CIRS) \> 6.
2. Creatinine clearance rate (Ccr) \<70 ml/min calculated by Cockcroft-Gault formula or by 24-hour urine analysis.
3. Patients diagnosed as other malignancy except lymphoma, except patients with curative intent and with no known active disease present for ≥ 5 years before the first dose of study drug and felt to be at low risk for recurrence by treating physician.
4. Patients with known central nervous system involvement.
5. Patients with progressive multifocal leukoencephalopathy (PML).
6. Patients with history of Richter's Syndrome or suspected Richter's Syndrome.
7. Uncontrolled autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura, e.g. persistent decreasing hemoglobin or platelet count requiring steroid therapy 4 weeks before initiation of study.
8. Prior exposure to systemic therapy for CLL/SLL (except for incomplete treatment regimens fewer than 2 weeks such as antitumor steroid therapy).
9. Prior exposure to live vaccines, immunotherapy or other investigational therapeutic agent within 4 weeks prior to enrollment.
10. Requiring persistent steroid therapy for other non-antitumor purposes. Systemic steroid drug use within 7 days of first dose of study drug except regional use of steroid drug.
11. Uncontrolled or other serious cardiovascular disease, including:

    1. New York Heart Association (NYHA) class II or higher congestive heart failure, unstable angina, myocardial infarction, or clinically significant arrhythmia requiring medical intervention with a left ventricular ejection fraction (LVEF) \<50% at screening 6 months prior to initial administration of the study drug;
    2. Primary cardiomyopathy (such as dilated cardiomyopathy, hypertrophic cardiomyopathy, rhythmogenesis right ventricular cardiomyopathy, restricted cardiomyopathy, unshaped cardiomyopathy);
    3. Clinically significant prolonged QTc interval, or QTc interval \>470 ms in female and \>450 ms in male at screening;
    4. Uncontrolled hypertension: on the basis of lifestyle improvement, blood pressure still fails to reach the standard after application of 2 or more kinds of reasonable, tolerable and full dose antihypertensive drugs (including diuretics), or 4 or more kinds of antihypertensive drugs until blood pressure can be effectively controlled.
12. Active bleeding within 2 months prior to screening, or taking anticoagulant/platelet drugs, or have a definite bleeding tendency in the investigator's opinion (e.g., esophageal varices with bleeding risk, local active ulcer lesions);
13. History of stroke or intracranial hemorrhage within 6 months prior to enrollment.
14. Clinically significant gastrointestinal abnormalities that may affect drug ingestion, transport, or absorption (e.g., inability to swallow, chronic diarrhea, intestinal obstruction, etc.), or total gastrectomy.
15. Major surgery within 4 weeks of first dose of study drug. Diagnostic examination is not regarded as surgery and insertion of vascular access device excluded from the criteria.
16. Uncontrolled active systemic fungi, bacteria, virus (e.g. CMV DNA positive by PCR analysis) or other infections (defined as showing persistent symptoms of infection and no improvement although appropriate antibiotics or other treatment have been applied), or requiring intravenous (IV) antibiotics administration.
17. Known human immunodeficiency virus (HIV) infection, or active hepatitis B or C infection (positive results from PCR analysis).
18. Known hypersensitivity to Orelabrutinib, Fludarabine, Cyclophosphamide or Obinutuzumab
19. Concurrent treatment with strong or moderate cytochrome P450, family 3, subfamily A (CYP3A) inhibitors or inducers.
20. Any mental or cognitive impairment that may limit their understanding of informed consent and compliance with the study.
21. Pregnant and lactating women, or women of childbearing age who are unwilling to use contraception throughout the study period and within 18 months of the last administration of obinutuzumab or within 180 days of the last administration of any other study drug (women who were fertile must have a negative serological pregnancy test within 14 days prior to initiation of study) Male without surgically sterilized who are unwilling to use contraception throughout the study period and within 180 days of the last administration of the study drug.
22. Any life-threatening illness, medical condition, or organ system dysfunction that, in the investigator's opinion, could compromise the subject's safety or put the study outcomes at undue risk.

Where this trial is running

Nanjin, Jiangsu

• Department of Haematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital — Nanjin, Jiangsu, China (RECRUITING)

Study contacts

• Principal investigator: Jianyong Li, Phd, MD — The First Affiliated Hospital with Nanjing Medical University
• Study coordinator: Jianyong Li, Phd, MD

Conditions: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma