Combining NMDA-enhancing and anti-inflammatory treatments for schizophrenia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of combining an NMDA-enhancing agent with an anti-inflammatory drug in treating patients with treatment-resistant schizophrenia. Participants will be randomly assigned to receive either the combination treatment or a placebo while maintaining their current antipsychotic regimen. The study will last for 12 weeks, during which clinical performance and cognitive functions will be assessed at multiple time points. The goal is to determine if the combined treatment offers superior benefits compared to the NMDA-enhancer alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have a DSM-5 (American Psychiatric Association) diagnosis of schizophrenia
* Are resistant to adequate treatments of at least two antipsychotics
* Remain symptomatic but without clinically significant fluctuation, while their antipsychotic doses are unchanged for at least 3 months and will be maintained during the period of the 12-week trial
* PANSS total score ≥ 70
* Agree to participate in the study and provide informed consent

Exclusion Criteria:

* DSM-5 diagnosis of intellectual disability or substance (including alcohol) use disorder
* History of epilepsy, head trauma, stroke, or serious medical or central nervous system diseases (other than schizophrenia) which may interfere with the study
* Clinically significant laboratory screening tests (including blood routine, biochemical tests)
* Pregnancy or lactation
* Inability to follow protocol

Where it's running

• Department of Psychiatry, China Medical University Hospital
  Taichung, Taiwan Recruiting

Study contacts

• Study coordinator: Hsien-Yuan Lane, M.D., Ph.D
• Email: hylane@gmail.com
• Phone: 886 4 22052121

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.