Combining nicotine patches and mouth spray to help quit vaping

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of a combination of nicotine patches and mouth spray compared to a nicotine tapering plan for vaping cessation. Conducted in New Zealand, it aims to determine which method, along with behavioral support, leads to higher rates of vaping abstinence after six months. Participants will be randomly assigned to one of the two treatment groups and will receive written support to aid their quitting efforts. The study targets individuals who vape regularly and are motivated to quit within the next eight weeks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Live in New Zealand.
* Vape nicotine at least weekly (one or more days out of the past seven days).
* Used to smoke (i.e. they have smoked tobacco regularly but not at all in the past six months) or have never smoked (i.e., they have never been a regular user of smoked tobacco, defined as less than 100 cigarettes in their lifetime).
* Are aged ≥16 years.
* Are motivated to quit vaping in the next eight weeks.
* Are able to provide consent.
* Have access to the internet via a computer or smart phone.
* Are a registered patient at a New Zealand medical facility.

Exclusion Criteria:

* They have another person in their household currently enrolled in the study.
* They smoke tobacco currently or were a recent regular user of tobacco.
* They are enrolled in another vaping cessation programme/trial.
* They self-report having had a serious cardiovascular event, or hospitalisation for a cardiovascular complaint, in the previous four weeks (e.g. stroke, myocardial infarction, unstable angina, cardiac arrhythmia, coronary artery bypass graft and angioplasty).
* They self-report uncontrolled hypertension.
* They have a strong preference to use/not use NRT or nicotine tapering.
* They are current users of smoking cessation pharmacotherapy (e.g. NRT, varenicline, cytisine, nortriptyline \[including if it is used for a different indication\], and amitriptyline \[as it converts to nortriptyline\].
* They are currently enrolled in another vaping cessation programme/trial.

Where it's running

• School of Population Health, Faculty of Medical and Health Sciences, University of Auckland
  Auckland, New Zealand Recruiting

Study contacts

• Principal investigator: George Laking, PhD, MBChB — University of Auckland, New Zealand
• Study coordinator: Amanda Calder, PhD
• Email: amanda.calder@auckland.ac.nz
• Phone: +64 9 373 7599

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Social media support groups to help teens and young adults quit vaping

  This pilot tries a social-media group program called the Quit the Hit Toolkit to help adolescents and young adults who vape stop using nicotine.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07540780

• Parents Helping Parents for Youth Vaping Cessation

  This project tests whether a parent-supported program can help teens quit vaping by pairing trained parent coaches with families.

  Recruiting University of Nebraska · Omaha, Nebraska · NCT07207850

• E-cigarette Cessation for Hispanic/Latino Teens in Florida

  This project tests a six-session, CBT-based e-cigarette cessation program tailored for Hispanic/Latino high school students to see if it helps reduce vaping use.

  Recruiting Florida International University · Miami, Florida · NCT07192601

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.