Combining microfracture surgery with platelet-rich plasma injection for ankle cartilage repair

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of combining arthroscopic microfracture surgery with an injection of platelet-rich plasma (PRP) gel in treating osteochondral lesions of the talus. Participants will either receive the combined treatment or undergo isolated microfracture surgery. The study will assess improvements in ankle function using the American Orthopedic Foot and Ankle Society (AOFAS) Score and evaluate the integration of the injured cartilage through MRI follow-ups. The goal is to determine if the addition of PRP gel enhances clinical outcomes compared to microfracture alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Chronic ankle pain, diagnosed as osteochondral lesion of the talus;
* Lesion size ≤ 1.5 cm2 or the diameter of the lesion ≤ 1.5 cm;
* Conservative treatment of at least 3 months fails to relieve symptoms;
* Willingness to voluntarily participate in the trial and to sign informed consent.

Exclusion Criteria:

* Varus or valgus deformity of the ankle of more than 5 degrees;
* Grade III injury of the lateral collateral ligament of ankle;
* Chronic synovitis (rheumatoid arthritis, pigmented villous nodular synovitis, etc.);
* Joint fibrosis, stiffness, and significantly restricted range of motion;
* Evidence of moderate to severe knee osteoarthritis on plain radiographs;
* Failure to complete the rehabilitation protocol as required;
* Patient medically not fit for surgery, radiographs or MRI;
* For women, pregnant, planning to be pregnant or lactating.

Where it's running

• Peking University Third Hospital
  Beijing, China Recruiting

Study contacts

• Principal investigator: Qinwei Guo, MD — Department of Sports Medicine, Peking University Third Hospital
• Study coordinator: Qinwei Guo, MD
• Email: guoqinwei@vip.sina.com
• Phone: +86 18601129252

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.