Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Combining mental rehearsal and vestibular therapy for relapsing‑remitting MS

Official title: The Effectiveness of Combination of Motor Imagery and Vestibular Rehabilitation on Balance, Cognition, and Quality of Life in Patients With Multiple Sclerosis

Run by Medipol University · NCT07230015 · Data updated 2026-11-12

This trial tests whether adding motor imagery (mental rehearsal) to vestibular rehabilitation improves balance, thinking, and quality of life in adults 18–45 with relapsing‑remitting MS who have mild cognitive and balance problems.

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment30 (estimated)
SponsorMedipol University
Academic / other
Locations1 site (Istanbul, Beykoz/İstanbul)
StatusRecruiting
StartedDecember 1, 2025
Main results expectedMay 30, 2026
Study endsJuly 20, 2026
Registry record updatedApril 30, 2026
Trial IDNCT07230015 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–45 with relapsing‑remitting MS, PDDS 0–3, mild cognitive impairment, mild-to-moderate balance problems related to vestibular dysfunction, and Arabic as their native language are ideal candidates.

Probably not a fit

People with progressive MS, non‑MS vestibular disorders, severe psychiatric or medical instability, severe fatigue or visual impairments, or who cannot communicate in Arabic or attend in-person sessions in Istanbul are unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial will test an 8-week combined program of motor imagery and vestibular rehabilitation against conventional therapy in people with relapsing‑remitting MS. Participants with mild disability (PDDS 0–3), mild cognitive impairment, and vestibular-related balance problems will be recruited and randomized to one of two groups. Outcomes include measures of balance, cognitive performance, physical function, and quality of life collected before and after the intervention. The study aims to determine whether integrating mental-rehearsal techniques with vestibular exercises produces broader or larger benefits than conventional therapy alone.

Why it matters

Potential benefit: If successful, the combined program could lead to better balance, improved cognition, and higher quality of life than standard therapy.

How similar studies have gone: Motor imagery and vestibular rehabilitation have each shown benefits in MS when studied separately, but combining them is novel and has not been previously tested in randomized trials.

Who can join: the full rules

Show full inclusion / exclusion criteria
inclusion criteria

1. Diagnosis of Multiple Sclerosis (MS) Confirmed using McDonald Criteria
2. Patient diagnosed relapsing-remitting multiple sclerosis (RRMS).
3. Mild MS between 0-3 according to PDDS.
4. Age from (18-45)
5. Mild cognitive impairment
6. Balance impairment (mild to moderate impairment)
7. Vestibular dysfunction Related to MS (dizziness, vertigo , gaze instability ) 8. Native language is Arabic to ensure clear communication during cognitive tasks and exercise instructions

9\. Be able to joined the treatment (motor imagery, vestibular rehabilitaiton )

Exclusion Criteria:

Other neurological disorder, progressive multiple sclerosis Non-MS related vestibular disorders (e.g., BPPV, Meniere's disease) that would interfere with vestibular rehab.

Severe Psychiatric Conditions (schizophrenia, bipolar, etc) Sever balance disorder Sever fatigue Medical instability eg (cardiovascular disease, respiratory, infections, severe uncontrolled diabetes, or severe visual impairments.) Sever cognitive impairment Pregnant Advance disability ( wheelchair , unable to stand ) Use of Vestibular-Suppressing Medications Non - speaker Arabic

Where it's running

  • Gehad Salem Mohamed Mohamed Menshawi
    Istanbul, Beykoz/İstanbul, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.