Combining LMV-12 with Osimertinib for advanced lung cancer

A Prospective Clinical Research of Efficacy and Safety of LMV-12(HE003) Combined With Osimertini in the Treatment of Advanced Non-small Cell Lung Cancer That Has Previously Failed From EGFR Inhibitor Therapy

This study is testing a new treatment combining LMV-12 with osimertinib to see if it can help people with advanced lung cancer who haven't responded to other treatments.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 120 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Hunan Province Tumor Hospital (Academic / other)
• Drugs / interventions: radiation, osimertinib
• Locations: 1 site (Changsha, Hunan)
• Trial ID: NCT06109558 on ClinicalTrials.gov

What this trial studies

This open-label, single-arm, dose-escalation clinical trial evaluates the safety and efficacy of LMV-12 (HE003) in combination with osimertinib for patients with advanced non-small cell lung cancer (NSCLC) who have not responded to previous treatments. The study is designed to assess the pharmacokinetic profile and tolerability of the treatment in various cohorts based on specific genetic mutations such as MET amplification and RET fusion. Participants will be monitored for safety and preliminary efficacy outcomes as they receive the combined therapy.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with advanced or metastatic NSCLC who have failed prior therapies and have specific genetic mutations.

Not a fit: Patients with early-stage lung cancer or those who have not previously undergone treatment may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with advanced NSCLC who have limited treatment alternatives.

How similar studies have performed: While the combination of targeted therapies is a common approach, the specific combination of LMV-12 and osimertinib in this context is novel and has not been extensively tested in prior studies.

Eligibility criteria

Inclusion Criteria:

* Eligible subjects selected for this study must meet all of the following criteria:

  1. Sign written informed consent before implementing any trial-related procedures;
  2. Age ≥18 years old;
  3. No limit on the gender;
  4. Histological or cytological confirmed advanced or metastatic non-small cell lung cancer, ineligible for radical surgery, relapse after failure of previous treatment with first-line (including first, second, and third generation)EGFR inhibitors.

     Cohort A：MET amplification,(by FISH, NGS or IHC) Cohort B：RET fusion.
  5. Laboratory tests for organ function levels must meet the following requirements:

     1. Absolute neutrophil count ≥ 1.5 × 109/L;
     2. Platelet count ≥ 100 × 109/L;
     3. Hemoglobin ≥ 9 g/dL;
     4. Bilirubin ≤1.5 times ULN; e) AST and ALT ≤2.5 times ULN (total bilirubin ≤3 times the upper limit of normal and AST and ALT ≤5 times the upper limit of normal are permitted if hepatic metastases are present);

     f) Serum creatinine ≤ 1.5 times ULN or creatinine clearance ≥ 60 mL/min (according to the Cockcroft-Gault formula);
  6. For premenopausal women of childbearing potential a pregnancy test must be performed within 7 days prior to initiation of treatment, a serum pregnancy test must be negative, and they must be non-lactating; all enrolled patients (whether male or female) should use adequate barrier contraception throughout the treatment period and for 3 months after completion of treatment.

Exclusion Criteria:

1. Subjects treated with CYP isozyme inducers or inhibitors (see Appendix 4 for details) within 3 weeks prior to enrollment;
2. Pregnant or lactating women;
3. History of immunodeficiency or other acquired, congenital immunodeficiency diseases;
4. Patients with prior bone marrow transplantation or prior solid organ transplantation;
5. Patients with a combination of gastrointestinal perforation, gastrointestinal fistula, or non-gastrointestinal fistula;
6. Prior history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis requiring steroid therapy, or any evidence of clinically active interstitial lung disease.
7. Hepatitis B, hepatitis C, or human immunodeficiency virus (HIV-positive). Hepatitis B is eligible for this study at \<500 IU/mL (or 2500 cps/mL) by quantitative HBV-DNA testing, and hepatitis C (HCV) antibody-positive patients are eligible for this study only if the polymerase chain reaction shows HCV RNA negativity;
8. Fulfillment of any of the following cardiac criteria: (i) Bazetts' mean corrected QT interval (QTc) derived from electrocardiogram (ECG) examination at rest \>470 msec (women) or \>450 msec (men) (in the case of the 1st abnormality, retested once within 48 h and calculated by averaging the results of the 2 times); and (ii) a wide variety of clinically significant rhythmic, conduction, and resting ECG morphologic Abnormalities, such as complete left bundle branch block, grade III conduction block, grade II conduction block, PR interval \>250 msec; (iii) Myocardial ischemia or myocardial infarction of grade I or higher, or congestive heart failure of grade ≥2 (New York Heart Association (NYHA) classification); (iv) Factors that may increase the risk of prolongation of QTc or the risk of arrhythmic events, such as coronary artery disease, heart failure hypokalemia, congenital long QT syndrome, family history of a first-degree relative with long QT syndrome or sudden unexplained death before the age of 40, and ongoing use of any medication known to prolong the QT interval;

Where this trial is running

Changsha, Hunan

• Hunan Cancer Hospital — Changsha, Hunan, China (Recruiting)

Study contacts

• Principal investigator: Nong Yang, MD — Hunan Cancer Hospital
• Study coordinator: Yongchang C Zhang, MD

Conditions Non Small Cell Lung Cancer; RET Gene Mutation; MET Amplification; EGF-R Positive Non-Small Cell Lung Cancer