Combining light therapy with CPAP for treating depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of two weeks of light therapy combined with continuous positive airway pressure (CPAP) on improving compliance in patients suffering from major depressive disorder (MDD) and obstructive sleep apnea (OSA). The study aims to recruit 130 adults diagnosed with MDD and OSA, assessing whether the addition of light therapy can enhance adherence to CPAP treatment. The trial is designed as a double-blind, parallel-group controlled trial, focusing on the relationship between sleep disturbances and depressive symptoms. By addressing both conditions simultaneously, the study seeks to improve overall patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults consulting at the MICHEL JOUVET unit, CH Le Vinatier, Bron
* Adults with a diagnosis of major depressive episode (DSM-V) and with a MADRS score ≥ 15
* Adults with a diagnosis of OSAS on ventilatory polygraphy or polysomnography (AASM 2017 criteria) requiring CPAP.

Exclusion Criteria:

* Refusal to participate.
* Pregnant and breast-feeding women
* Under guardianship or curatorship.
* Unstable psychiatric or physical pathology (e.g., hypomania, high suicidal risk) considered incompatible with the study by the investigators.
* Other psychiatric, neurologic or somatic conditions
* Contraindication to light therapy: retinopathy, retinitis pigmentosa, diabetic retinopathy, macular degeneration, glaucoma, recent eye surgery (less than 3 months).

patient wishing to choose a provider other than the protocol provider.

* Patient wishing to choose a device other than SEFAM's S-BOX or a mask other than the nasal mask at the time of introduction.
* Nasal obstruction.
* Refusal to use actimetry, refusal to use light therapy, refusal to use CPAP.

Where it's running

• Centre Hospitalier le Vinatier
  Bron, France, France Recruiting
• Centre Hospitalier le Vinatier
  Bron, France Not yet recruiting

Study contacts

• Principal investigator: Sébastien S CATOIRE, DR — Centre Hospitalier le Vinatier
• Study coordinator: Sébastien S CATOIRE, Dr
• Email: sebastien.catoire@ch-le-vinatier.fr
• Phone: +330437915495

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.