Combining light therapy with CPAP for treating depression

Effects of Light Therapy on Compliance With Continuous Positive Airway Pressure in a Population of Depressed Patients Newly Fitted With Devices for Obstructive Sleep Apnea

This study is testing if adding light therapy to CPAP treatment can help adults with depression and sleep apnea stick to their therapy better.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 130 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Hôpital le Vinatier (other)
• Locations: 2 sites (Bron, France and 1 other locations)
• Trial ID: NCT06781593 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effects of two weeks of light therapy combined with continuous positive airway pressure (CPAP) on improving compliance in patients suffering from major depressive disorder (MDD) and obstructive sleep apnea (OSA). The study aims to recruit 130 adults diagnosed with MDD and OSA, assessing whether the addition of light therapy can enhance adherence to CPAP treatment. The trial is designed as a double-blind, parallel-group controlled trial, focusing on the relationship between sleep disturbances and depressive symptoms. By addressing both conditions simultaneously, the study seeks to improve overall patient outcomes.

Who should consider this trial

Good fit: Ideal candidates include adults diagnosed with major depressive disorder and obstructive sleep apnea who require CPAP treatment.

Not a fit: Patients with unstable psychiatric conditions or contraindications to light therapy may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly improve CPAP compliance and alleviate depressive symptoms in patients with MDD and OSA.

How similar studies have performed: While the combination of light therapy and CPAP is a novel approach, existing studies have shown that treating sleep disturbances can improve depressive symptoms.

Eligibility criteria

Inclusion Criteria:

* Adults consulting at the MICHEL JOUVET unit, CH Le Vinatier, Bron
* Adults with a diagnosis of major depressive episode (DSM-V) and with a MADRS score ≥ 15
* Adults with a diagnosis of OSAS on ventilatory polygraphy or polysomnography (AASM 2017 criteria) requiring CPAP.

Exclusion Criteria:

* Refusal to participate.
* Pregnant and breast-feeding women
* Under guardianship or curatorship.
* Unstable psychiatric or physical pathology (e.g., hypomania, high suicidal risk) considered incompatible with the study by the investigators.
* Other psychiatric, neurologic or somatic conditions
* Contraindication to light therapy: retinopathy, retinitis pigmentosa, diabetic retinopathy, macular degeneration, glaucoma, recent eye surgery (less than 3 months).

patient wishing to choose a provider other than the protocol provider.

* Patient wishing to choose a device other than SEFAM's S-BOX or a mask other than the nasal mask at the time of introduction.
* Nasal obstruction.
* Refusal to use actimetry, refusal to use light therapy, refusal to use CPAP.

Where this trial is running

Bron, France and 1 other locations

• Centre Hospitalier le Vinatier — Bron, France, France (RECRUITING)
• Centre Hospitalier le Vinatier — Bron, France (NOT_YET_RECRUITING)

Study contacts

• Principal investigator: Sébastien S CATOIRE, DR — Centre Hospitalier le Vinatier
• Study coordinator: Sébastien S CATOIRE, Dr

Conditions: Major Depression, Sleep Architecture, Obstructive Sleep Apnea, Compliance, Continuous Positive Airway Pressure, Light Therapy