Combining immune treatment and precision radiotherapy for lung cancer brain metastasis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial is a prospective multicenter study aimed at developing a decision-making system for treating lung cancer with brain metastases. It combines immunotherapy with large-segmentation precision radiotherapy, utilizing imagomics, clinicopathological features, and molecular pathological features to enhance treatment outcomes. The study focuses on patients with confirmed non-small cell lung cancer who have asymptomatic brain metastases and meet specific eligibility criteria. The approach seeks to optimize treatment strategies for this challenging condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years of age on day of signing informed consent
* Histopathology confirmed non-small cell lung cancer
* Asymptomatic brain metastases
* EGFR/ALK ROS1 driver gene mutation negative
* RECIST 1.1 based available assessment of lesions
* ECOG 0-1
* Brain metastases 1-4
* Single lesion ≤4cm

Exclusion Criteria:

* Patients with contraindication of chemotherapy Pregnant or breast feeding women

Where it's running

• Hunan Cancer Hospital
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: Yongchang C Zhang, MD
• Email: zhangyongchang@csu.edu.cn
• Phone: +8613873123436

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.