Combining GATT with Goniosynechiolysis for Glaucoma Treatment
Outcome of Gonioscopy-Assisted Transluminal Trabeculotomy Combined With Goniosynechiolysis in Glaucoma Patients With Secondary Synechial Angle Closure: A Prospective Case Series
This study is testing a new surgery that combines two techniques to help lower eye pressure in patients with a specific type of glaucoma that hasn't responded well to medication.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 23 (estimated) |
| Sex | All |
| Sponsor | Kasr El Aini Hospital Academic / other |
| Locations | 1 site (Giza) |
| Trial ID | NCT06445634 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of a combined surgical approach using gonioscopy-assisted transluminal trabeculotomy (GATT) and goniosynechialysis in patients suffering from secondary synechial angle closure glaucoma. The goal is to reduce intraocular pressure (IOP) in patients who have not achieved adequate control with maximum medical therapy. The procedure involves creating a circumferential incision in the trabecular meshwork to facilitate aqueous humor drainage. This innovative technique aims to improve patient outcomes in a condition that can lead to irreversible blindness.
Who should consider this trial
Good fit: Ideal candidates include patients with secondary synechial angle closure glaucoma requiring surgical intervention for uncontrolled IOP.
Not a fit: Patients with primary angle-closure glaucoma, neovascular glaucoma, or significant retinal or corneal pathology may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly lower intraocular pressure in patients with secondary angle closure glaucoma, potentially preserving vision.
How similar studies have performed: Previous studies have shown favorable outcomes when combining GATT with other surgical techniques, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with secondary synechial angle closure glaucoma * Involving more than 180 degrees of the iridocorneal angle * Requiring surgery for uncontrolled IOP despite maximum tolerated therapy. Exclusion Criteria: * Eyes with PACG. * Eyes with neovascular glaucoma. (Some apparently stable NVG cases would have remnants of neo-vessels in the angle that are hidden behind the synechiae). * Eyes with retinal pathology. * Eyes requiring combined phacoemulsification and GATT. * Eyes with corneal pathology that can preclude surgery and imaging.
Where this trial is running
Giza
- Kasralainy Hospitals — Giza, Egypt (Recruiting)
Study contacts
- Study coordinator: Rokaya Radwan
- Email: rokaia.e.radwan@students.kasralainy.edu.eg
- Phone: 01066471468
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.