Combining Furmonertinib and Anlotinib for Advanced Lung Cancer with Brain Metastasis

A Prospective, Single-arm, Multi-center Clinical Trial of Furmonertinib Combined With Anlotinib as First-line Treatment for Advanced NSCLC With EGFR-sensitive Mutations and Brain Metastasis.

This study is testing if combining two drugs, Furmonertinib and Anlotinib, can help people with advanced lung cancer that has spread to the brain feel better and live longer.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 146 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Henan Cancer Hospital (Government)
• Drugs / interventions: furmonertinib, anlotinib, chemotherapy, immunotherapy, radiation
• Locations: 1 site (Zhengzhou)
• Trial ID: NCT06945705 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness of Furmonertinib, a novel EGFR-TKI, combined with Anlotinib as a first-line treatment for patients with advanced non-small cell lung cancer (NSCLC) who have EGFR-sensitive mutations and brain metastases. The study aims to improve treatment outcomes for patients with a poor prognosis due to brain involvement. By leveraging the enhanced intracranial distribution of Furmonertinib, the trial seeks to delay disease progression and improve overall survival rates. Patients will be monitored for their response to the treatment and any potential side effects.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with confirmed advanced NSCLC and specific EGFR mutations, along with brain metastases.

Not a fit: Patients without EGFR-sensitive mutations or those with early-stage NSCLC may not benefit from this treatment.

Why it matters

Potential benefit: If successful, this treatment could significantly improve survival and quality of life for patients with advanced NSCLC and brain metastases.

How similar studies have performed: Previous studies have shown promising results with EGFR-TKI combination therapies, indicating potential for success in this novel approach.

Eligibility criteria

Inclusion Criteria:

* Patient must meet all of the following inclusion criteria to be enrolled in this study:

  1. Patients must voluntarily agree to participate in the study and sign a written informed consent form.
  2. Patients must be ≥18 years old, regardless of gender.
  3. Patients must have histologically or cytologically confirmed advanced NSCLC, staged as AJCC TNM 9th edition Stage IV.
  4. Histological or cytological report issued by a hospital or a third-party testing institution recognized by the national assessment confirmed the presence of EGFR 19Del or L858R mutations, with or without other EGFR mutations.
  5. Patients must have an ECOG performance status score of 0-2 and be expected to survive for at least 12 weeks, as determined by the investigator.
  6. Patients must have brain parenchymal metastases confirmed by CT or MRI scans, with or without symptoms (as judged by the investigator).
  7. Patients must have at least one measurable lesion based on RECIST 1.1 criteria.
  8. Patients must not have received prior systemic anticancer therapy for advanced/metastatic NSCLC, including standard chemotherapy, biological therapy, targeted therapy, immunotherapy, or investigational drug therapy. Patients who received adjuvant or neoadjuvant therapy (chemotherapy and/or radiotherapy) are eligible if there has been no disease progression within 6 months of treatment completion. Patients who received local therapy (radiotherapy or pleural perfusion therapy) are also eligible if the treated lesion is not a target lesion.
  9. Patients must meet the following organ function criteria:

     Absolute neutrophil count (ANC) ≥1.5 × 10⁹/L. Platelet count ≥75 × 10⁹/L. Hemoglobin (HGB) ≥80 g/L. Serum total bilirubin (TBIL) ≤1.5 times the upper limit of normal (ULN). For patients with liver metastases, TBIL may be up to 3 times ULN. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 times ULN.

     For patients with liver metastases, AST and ALT may be up to 5 times ULN. Serum creatinine (SCr) ≤1.5 times ULN, or creatinine clearance rate ≥50 mL/min (calculated using the Cockcroft-Gault formula).
  10. Male patients with reproductive potential and female patients with a possibility of pregnancy must use highly effective contraceptive methods (e.g., oral contraceptives, intrauterine devices, abstinence, or barrier contraception combined with spermicide) during the study and for 12 months after treatment discontinuation.

Exclusion Criteria:

* Patients with any of the following criteria are not eligible for enrollment in this study:

  1. Patients whose diagnosis cannot be confirmed as non-small cell lung cancer (NSCLC) through histological or cytological examination.
  2. Patients who have leptomeningeal metastasis confirmed by MRI and/or positive cerebrospinal fluid (CSF) cytology, but no evidence of brain parenchymal metastasis.
  3. Patients who are expected to require other systemic anticancer therapies outside of this study during the trial period.
  4. Patients with a history of malignancies diagnosed within the past 2 years, excluding well-controlled basal cell carcinoma of the skin, cervical carcinoma in situ, or ductal carcinoma in situ of the breast.
  5. Patients with significant gastrointestinal diseases that may affect drug intake or absorption, including but not limited to peptic ulcers or inflammatory bowel disease.
  6. Patients with known or suspected allergies to the study drugs (furmonertinib and anlotinib) or any components of their formulations.
  7. Patients who have previously received any epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy.
  8. Patients who have used strong CYP3A4 inhibitors or inducers within 7 days before the first dose of the study drug or are expected to require long-term use during the trial. Additionally, patients who have used Chinese herbal medicine or formulations with an antitumor indication within 2 weeks before the first dose or are expected to require such use during the trial.
  9. Patients with a history of interstitial lung disease, drug-induced ILD, or radiation pneumonitis requiring corticosteroid therapy. Patients with acute exacerbation or progressive pulmonary symptoms at baseline, or those deemed unsuitable for enrollment by the investigator due to high-risk factors for ILD, are also excluded.
  10. Patients with significant arrhythmias (e.g., QT interval \>470 ms) or heart failure (left ventricular ejection fraction \<50%).
  11. Pregnant or breastfeeding women.
  12. Patients who are currently participating in or have participated in other clinical trials within the past 4 weeks.
  13. Patients with severe acute or chronic medical or psychiatric conditions, as judged by the investigator, that may increase the risks associated with participation in the study or interfere with the interpretation of study results. This also includes patients who are unlikely to complete the study or comply with its requirements due to management-related or other reasons.

Where this trial is running

Zhengzhou

• Henan Cancer Hospital — Zhengzhou, China (Recruiting)

Study contacts

• Study coordinator: Fangfang Gao

Conditions NSCLC; EGFR