Combining exercise and cognitive training to prevent Alzheimer's in older adults at risk
Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study)
NA · University of Minnesota · NCT06340659
This study is testing if combining exercise with brain training can help older adults at risk of Alzheimer's stay mentally sharp and prevent dementia.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 104 (estimated) |
| Ages | 65 Years to 99 Years |
| Sex | All |
| Sponsor | University of Minnesota (other) |
| Locations | 1 site (Minneapolis, Minnesota) |
| Trial ID | NCT06340659 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the effectiveness of concurrent aerobic exercise and cognitive training in preventing Alzheimer's disease in older adults who are at risk due to subjective cognitive decline. Participants aged 65 and older will engage in a program that includes both physical activity and cognitive exercises, with the goal of improving cognitive function and reducing the risk of developing dementia. The study will assess the impact of these interventions on cognitive health over time, utilizing measures such as the Montreal Cognitive Assessment. By targeting individuals who report cognitive difficulties but do not yet have a formal diagnosis of dementia, the study seeks to intervene early in the Alzheimer's disease continuum.
Who should consider this trial
Good fit: Ideal candidates for this study are English-speaking adults aged 65 and older who report cognitive complaints but do not have a diagnosis of dementia or mild cognitive impairment.
Not a fit: Patients who have a confirmed diagnosis of dementia or mild cognitive impairment, as well as those with significant neurological or psychiatric disorders, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of Alzheimer's disease among at-risk older adults.
How similar studies have performed: Other studies have shown promise in using combined physical and cognitive interventions to improve cognitive outcomes in older adults, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cognitive complaint (defined as answering yes to the questions's "Do you perceive memory or cognitve difficulties?" and "In the last two years, has your cognition or memory declined?"; * Montreal Cognitive Assessement (MoCA) 26 or greater * Age 65 years and older; * English-speaking; * Without ACSM contraindication to exercise Exclusion Criteria: * Dementia or mild cognitive impairment diagnosis; * Neurological or major psychiatric disorder, alcohol/chemical dependency or recent medical condition (anethesia COVID-19 \["brain fog"\]) likely causing cognitive impairment; * Current enrollment in another intervention study
Where this trial is running
Minneapolis, Minnesota
- University of Minnesota — Minneapolis, Minnesota, United States (RECRUITING)
Study contacts
- Study coordinator: Dereck Salisbury
- Email: salis048@umn.edu
- Phone: 612-625-9308
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: At Risk for AD-dementia, With Subjective Cognitive Decline