Combining Desmopressin with Tamsulosin to Treat BPH Symptoms
Outcome of Adding Desmopressin to Tamsulosin for Treatment of Nocturnal Polyurea in Patients With Benign Prostatic Obstruction
This study is testing if adding desmopressin to tamsulosin can help men over 50 with BPH who have trouble with nighttime urination feel better.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 160 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | Male |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Mansoura, Outside U.S./Canada) |
| Trial ID | NCT05945420 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of adding desmopressin to tamsulosin in men over 50 with benign prostatic hyperplasia (BPH) who experience nocturnal polyuria. Participants will be divided into two groups: one receiving tamsulosin and desmopressin, and the other receiving tamsulosin and a placebo. The study aims to compare the outcomes related to nocturia and overall urinary symptoms associated with BPH. By assessing these outcomes, the study seeks to determine the efficacy of this combination therapy.
Who should consider this trial
Good fit: Ideal candidates are men over 50 with BPH experiencing nocturia and nocturnal polyuria.
Not a fit: Patients with acute urinary retention, neurogenic bladder dysfunction, or other specified exclusion criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve urinary symptoms and quality of life for patients with BPH.
How similar studies have performed: While the combination of desmopressin and tamsulosin is a novel approach, similar studies have shown promise in managing urinary symptoms in BPH patients.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Men with BPH Age more than 50years Patients with nocturia (2voids per night or More) Patients with nocturnal polyurea (urine volume More than 33%of urine allover the day) IPSS more than 12 Obstructed flow curve Post voiding residual less than 150 Exclusion Criteria: * men with BPH with : Acute urine retention Neurogenic bladder dysfunction Cardiovascular disease Hyponatremia Urethral stricture Bladder calculi Prostate cancer
Where this trial is running
Mansoura, Outside U.S./Canada
- Urology and nephrology center — Mansoura, Outside U.S./Canada, Egypt (Recruiting)
Study contacts
- Study coordinator: Ahmed Azmy, Resident
- Email: dr.a.azmy93@gmail.com
- Phone: +20 01010623936
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.