Combining cognitive restructuring and mindfulness for anxiety and depression treatment

Combining Treatment Components in Transdiagnostic Therapy for Anxiety and Depression: A Randomized Controlled Trial

This study is testing whether combining two therapy techniques, cognitive restructuring and mindfulness, can help people with anxiety and depression feel better.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 93 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: University of Aarhus (Academic / other)
• Locations: 1 site (Aarhus)
• Trial ID: NCT06429956 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effects of combining cognitive restructuring and detached mindfulness, two components of cognitive behavioral therapy, on patients with anxiety and depression. It aims to explore the effectiveness of these treatments both individually and in combination, while also examining demographic and clinical factors that may influence outcomes. The study is designed as a randomized controlled trial, ensuring rigorous assessment of the treatment effects. Participants will engage in online therapy sessions, allowing for a flexible and accessible approach to mental health care.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with a diagnosis of anxiety disorders or mild to moderate major depressive disorder who are proficient in Danish.

Not a fit: Patients with severe depression, persistent depressive disorder, or those currently receiving other forms of psychotherapy may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to more effective and personalized treatment options for individuals suffering from anxiety and depression.

How similar studies have performed: Previous studies have shown promise in combining different therapeutic components, suggesting that this approach may yield beneficial results.

Eligibility criteria

Inclusion Criteria:

1. Age ≥ 18 years.
2. A diagnosis of an anxiety disorder (generalized anxiety disorder, social anxiety disorder, or panic disorder with or without agoraphobia) and/or mild to moderate major depressive disorder (MDD) according to DSM-5 (American Psychiatric Association, 2022).
3. Danish language proficiency.
4. Ability and willingness to give informed consent.
5. No or stable antidepressant/antianxiety medication (i.e., same dosage for ≥ 8 weeks).
6. Access to either a smartphone, tablet, or computer with video camera.

Exclusion Criteria:

1. Severe depression deemed to require more intense psychotherapy or medication.
2. Persistent depressive disorder (i.e., depressive symptoms have persisted for 2 years or more).
3. Non-stabilized medication (see above).
4. Currently receiving other psychotherapy or counseling.
5. Not capable of participating online.
6. Lack of Danish proficiency.
7. A history of bipolar disorder.
8. Current or past psychosis.
9. Substance abuse or dependence judged to require treatment.
10. Suicide risk requiring immediate hospitalization.

Where this trial is running

Aarhus

• Department of Psychology and Behavioral Sciences — Aarhus, Denmark (Recruiting)

Study contacts

• Principal investigator: Caroline Nørskov, MSc — University of Aarhus
• Study coordinator: Caroline Nørskov, MSc

Conditions Depression; Anxiety