Combining chemotherapy and targeted therapy for early HER2 positive breast cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness and safety of combining chemotherapy with targeted therapy for patients with high-risk HER2 positive early breast cancer who have negative lymph nodes. The aim is to explore whether reducing chemotherapy while incorporating targeted treatments can maintain efficacy and minimize toxicity. The study focuses on patients who have undergone radical resection and have specific pathological characteristics indicating high risk. By stratifying patients based on risk factors, the research seeks to optimize treatment strategies for this subgroup.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\) Treated in Peking University People's Hospital and underwent radical resection with hospitalization records;
* 2\) Postoperative pathology confirmed invasive breast cancer, pathological staging was T2, N0, HER2 positive, and accompanied by one of the high-risk factors (G3, or hormone receptor negative);
* 3\) Has signed and agreed to participate in the PKUPH breast disease cohort study.

Exclusion Criteria:

* 1\) Lack of clinical and pathological data (such as imaging data and pathological data);
* 2\) Preoperative neoadjuvant therapy;
* 3\) Patients with metastatic breast cancer or bilateral breast cancer;
* 4\) Failure to perform radical surgery.

Where it's running

• Peking University People's Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: yuan peng, doctor
• Email: 13671287670@163.com
• Phone: 86+13671287670

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.