Combining Bemcentinib and Pacritinib for Advanced Lung Adenocarcinoma

A Phase Ib/II Open-Label, Dose-Escalation, Safety, Pharmacokinetic, Pharmacodynamic and Efficacy Study of Bemcentinib Plus Pacritinib In Patients With Advanced Lung Adenocarcinoma

This study is testing a new combination of two drugs, bemcentinib and pacritinib, to see if they can help people with advanced lung adenocarcinoma who haven't had success with other treatments.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 44 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: The University of Texas Health Science Center at San Antonio (Academic / other)
• Drugs / interventions: pacritinib, bemcentinib, chemotherapy, radiation
• Locations: 1 site (San Antonio, Texas)
• Trial ID: NCT06516887 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the safety and efficacy of combining bemcentinib, an AXL inhibitor, with pacritinib, a JAK2 inhibitor, in patients with advanced lung adenocarcinoma who have not responded to previous treatments. The study is designed as a Phase Ib/II, open-label, single institution trial that will determine the maximum tolerated dose (MTD) of the drug combination using a Bayesian Optimal Interval design. Participants will receive escalating doses of the combination therapy until the MTD is established, while monitoring for safety, tolerability, and pharmacokinetics. The trial aims to provide insights into the potential effectiveness of this novel treatment approach for a challenging cancer type.

Who should consider this trial

Good fit: Ideal candidates include adults with advanced lung adenocarcinoma who have failed at least one line of systemic treatment and do not have actionable driver mutations.

Not a fit: Patients with early-stage lung cancer or those who have not yet undergone systemic treatment may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could offer a new therapeutic option for patients with advanced lung adenocarcinoma who have limited treatment choices.

How similar studies have performed: While the combination of these specific drugs is being explored in this trial, similar approaches using targeted therapies have shown promise in other studies.

Eligibility criteria

Inclusion Criteria:

1. Patients with histologically-or cytologically confirmed diagnosis of locally advanced and/or metastatic lung adenocarcinoma (Stage IV/AJCC Edition 8) (any PD-L1 status) without actionable driver mutations, who has failed at least one line of systemic treatment. Patients with locally advanced and/or metastatic lung adenocarcinoma with driver mutation who have failed standard targeted therapies can also be enrolled on this study.
2. Be refractory to, or intolerant of, an established therapy known to provide clinical benefit for their condition. Patients can be eligible for study if they have failed at least one line of treatment.
3. Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 as assessed by the investigator. Evaluable disease in phase 1 is allowed.
4. Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 (AppendixH)
5. Life expectancy of at least 3 months
6. Be ≥18 years of age
7. Negative pregnancy test (if female of childbearing potential)
8. Adequate liver function:

   * Total bilirubin \<1.5x upper limit of normal (ULN) (\<3xULN for subjects with liver metastases)
   * Aspartate aminotransferase (AST/SGOT), alanine aminotransferase (ALT/SGPT), alkaline phosphatase \<2.5 x ULN.

     * If liver metastases are present, then AST and ALT \<5 x ULN is allowed.
9. Adequate renal function with calculated creatinine clearance ≥30 mL/min by Cockcroft-Gault Formula.
10. Adequate hematologic status:

    * Absolute neutrophil count ≥1500 cells/mm3
    * Platelet count ≥100,000 (plt/mm3)
    * Hemoglobin ≥9 g/dL
11. Have no clinically significant abnormalities on urinalysis
12. Have acceptable coagulation status:

    * Prothrombin time (PT) ≤ 1.5 x ULN
    * Activated partial thromboplastin time (aPTT) ≤ 1.5 x ULN
13. Be non-fertile or agree to use an adequate method of contraception. Sexually active patients and their partners must use an highly effective method of contraception (hormonal or barrier method of birth control; or abstinence) prior to study entry and for the duration of study participation and for at least 90 days after the last study drug dose. Female patients using hormonal contraceptive agent should use at least one additional non-hormonal method of contraception (e.g., IUD, condom, abstinence). Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
14. Have read and signed the IRB-approved informed consent form prior to any study related procedure. If a patient is re-screened for the clinical trial or a protocol amendment alters the care of an ongoing patient, a new informed consent form must be signed.
15. Patients enrolled in the Expansion Cohort must be willing to consider pre-study and on-study biopsies, if safe and medically feasible, as determined by a board-certified interventional radiologist. Four to eight core samples will be requested at each biopsy timepoint.
16. Patients must be able to swallow and tolerate oral medications.

Exclusion Criteria:

1. History of the following cardiac conditions:

   1. An acute ischemic cardiac event (e.g., myocardial infarction) or hospitalization for unstable angina within 3 months prior to first dose.
   2. Abnormal left ventricular ejection fraction on echocardiography (less than the lower limit of normal for a subject of that age at the treating institution or Grade 2 severity according to the New York Heart Association as defined by symptoms at less than ordinary levels of activity. Echo will only be considered for symptomatic patients with heart disease and concerns for heart failure. The Echo would be ordered by PI as standard of care.
   3. Uncontrolled cardiac disease, including unstable angina, uncontrolled hypertension (i.e., sustained systolic BP \>160 mmHg or diastolic BP \>90 mmHg), or need to change medication due to lack of disease control within 12 weeks prior to the provision of consent.
   4. History or presence of bradycardia (≤55 bpm) or history of symptomatic bradycardia, left bundle branch block, cardiac pacemaker or significant atrial tachyarrhythmias as defined by the need for treatment.
   5. Presence of any factors that increase the risk for QTc prolongation, e.g., resistant, or inadequately treated heart failure, presence of hypokalemia or hypomagnesemia not corrected by, or not responding to, replacement therapy or inadequately treated hypothyroidism as defined by the thyroid-stimulating hormone not within the expected range of the institution.
   6. Family history of long QTc syndrome or ventricular arrhythmias; personal history of long QTc syndrome or previous drug induced QTc prolongation of at least Grade 3 (QTc \>500 ms). (Appendix I)
2. Have a corrected QT interval (QTcF, Fridericia's method) of \>450 msec in men and \>470 msec in women.
3. Presence of symptomatic central nervous system metastatic disease that requires local therapy such as radiotherapy, surgery, or increasing dose of steroids within 2 weeks prior to Day 1 treatment.
4. Have undergone major surgery, other than diagnostic surgery, within 2 weeks prior to Day 1
5. Have active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy.
6. Are pregnant or nursing.
7. Received treatment with radiation therapy, chemotherapy, or investigational therapy within 28 days or 5 half-lives, whichever occurs first, prior to study entry.
8. Are unwilling or unable to comply with procedures required in this protocol.
9. Have known infection with human immunodeficiency virus, hepatitis B, or hepatitis C. Patients with history of chronic hepatitis that is not active are eligible.
10. Have a serious nonmalignant disease (e.g., hydronephrosis, liver failure (Child Pugh class B or C), or other conditions) that could compromise protocol objectives in the opinion of the clinical investigators.
11. Uncontrolled diarrhea (grade ≥ 2).
12. Recent bleeding (grade ≥2 within the past 3 months unless precipitated by another event (e.g., trauma, surgery).
13. Use of anticoagulant or anti-platelet agents within the prior 14 days other than baby aspirin.
14. Use of strong CYP3A4 inducers or inhibitors within 5 half-lives prior to cycle 1 day 1 treatment. Patients enrolled in PK study should not be taking a moderate/severe CYP3A4 inhibitor or inducer.
15. Are currently receiving any other investigational agent.
16. Have exhibited allergic reactions to a similar structural compound or formulation as pacritinib or bemcentinib.
17. Patients with severe lactose intolerance, hereditary galactose intolerance, LAPP-lactase deficiency and/or glucose-galactose malabsorption at the discretion of the PI\>.
18. Have undergone significant surgery to the gastrointestinal tract that could impair absorption or that could result in short bowel syndrome with diarrhea due to malabsorption.
19. Have a history of severe adverse reaction (e.g., hypersensitivity reaction, anaphylaxis) to sulfonamides.
20. Patients who are currently taking H2-receptor agonists (e.g., cimetidine, ranitidine) or proton pump inhibitors (e.g., omeprazole) must be able to discontinue their use at least seven days prior to the first dose of study treatment and throughout the period they are receiving study treatment. Patients who are unable to do so will be deemed ineligible.
21. Patients with retinopathy. Other ophthalmologic diseases may be allowed at the investigator's discretion.

Where this trial is running

San Antonio, Texas

• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States (Recruiting)

Study contacts

• Study coordinator: Kayla Chamberlain

Conditions Advanced Lung Adenocarcinoma