Combining Amantadine with Pregabalin to Manage Post-thoracotomy Pain
Effectiveness of Adding Amantadine to Pregabalin on Occurrence of Post-thoracotomy Pain Syndrome; Randomized Controlled Study
This study is testing if adding Amantadine to Pregabalin can help lung cancer patients feel less pain after their surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06833203 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of adding Amantadine to Pregabalin in preventing post-thoracotomy pain syndrome in lung cancer patients undergoing thoracotomy. The research focuses on how these medications interact to reduce pain by targeting specific receptors in the nervous system. Participants will be cancer patients aged 18-65 who are scheduled for lung resection surgeries. The study aims to determine if this combination therapy can improve pain management outcomes compared to Pregabalin alone.
Who should consider this trial
Good fit: Ideal candidates are cancer patients aged 18-65 undergoing thoracotomy for lung cancer or related conditions.
Not a fit: Patients with severe respiratory or cardiac disorders, or those with a history of psychological disorders or chronic pain may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve pain management for patients recovering from thoracotomy surgeries.
How similar studies have performed: While the combination of these specific drugs has not been extensively tested together, similar approaches using NMDA antagonists and anticonvulsants have shown promise in pain management.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age (18-65) years. * Both sexes. * American Society of Anesthesiologists (ASA) Physical status II, III. * Body mass index (BMI): (20-40) kg/m2. * Cancer patients undergoing posterolateral thoracotomy incision for cancer lung, mesothelioma or other lung resection procedures. Exclusion Criteria: * Patients with known sensitivity or contraindication to drug used in the study. * History of psychological disorders and/or chronic pain and drug abuse patients. * Previous administration of antidepressants, anticonvulsants, or opioids before surgery. * Patient refusal. * Severe respiratory or cardiac disorders. * Advanced liver or kidney disease.
Where this trial is running
Cairo
- Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Samuel B Moawad, Master
- Email: Sambekhet@gmail.com
- Phone: 00201285193855
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.