Combined screening for gastrointestinal tumors
A Population-based, Multicenter Cohort Study of Combined Screening for Gastrointestinal Tumors
This study is testing whether using a combination of screening tests for gastrointestinal tumors can help people aged 45 to 70 catch cancers earlier and improve their health outcomes compared to limited testing.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 84000 (estimated) |
| Ages | 45 Years to 70 Years |
| Sex | All |
| Sponsor | Xijing Hospital Academic / other |
| Locations | 1 site (Zhaoqing, Guangzhou) |
| Trial ID | NCT05996458 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the feasibility and health economic benefits of combined screening methods for gastrointestinal tumors, including esophagus, stomach, and colorectal cancers. Participants aged 45 to 70 will undergo a series of tests, including gastroscopy, colonoscopy, and various genetic and risk factor assessments. The study will compare outcomes between two groups: one receiving comprehensive screening and another with limited testing, with a follow-up period of 10 years to observe health outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 45 to 70 who are willing to participate in extensive screening for gastrointestinal cancers.
Not a fit: Patients with a history of any type of malignancy or recent gastrointestinal surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of gastrointestinal tumors, potentially reducing mortality rates.
How similar studies have performed: Other studies have shown success with similar screening approaches, indicating potential for effective early detection of gastrointestinal cancers.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Subjects were 45 to 70 years old when enrolled 2. Willing and able to sign informed consent Exclusion Criteria: * 1\. History of any type of malignancy 2. Previous resection of esophagus, stomach or colorectal 3. Received gastrointestinal endoscopy such as colonoscopy and gastroscopy in recent 5 years 4. Have received fecal occult blood test and fecal DNA test in the past 1 year. 5. Contraindications to endoscopy. 6. Warning symptoms of digestive tract tumors, including: 1. Difficulty swallowing, choking or halting feeling when eating recently 2. Recent esophageal foreign body sensation or swallowing pain 3. Recent long-term loss of appetite and appetite 4. Recent and prolonged symptoms of indigestion (including acid reflux, heartburn, abdominal grumbling, burping, nausea or premature satiety, etc.) 5. Recent symptoms of abdominal mass, abdominal pain, vomiting or hematemesis 6. It was medically diagnosed as iron deficiency anemia 7. Recent changes in hematochezia, black stool or stool character and frequency 8. Recent symptoms of perianal discomfort (including soreness, itching, lumps, prolapse or other discomfort) 9. Unexplained weight loss (more than 10% of base body weight) in the past 6 months Step 7 Get pregnant 8. There are other serious comorbiditions that reduce screening benefits (including severe lung disease, advanced kidney disease, advanced liver disease, severe heart failure, etc.)
Where this trial is running
Zhaoqing, Guangzhou
- Gaoyao District People's Hospital — Zhaoqing, Guangzhou, China (Recruiting)
Study contacts
- Study coordinator: rong zheng
- Email: zhengrong4956@163.com
- Phone: 19829758242
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.