Combined processed EEG (PSi) and near-infrared spectroscopy (NIRS) monitoring to prevent postoperative cognitive problems after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional protocol enrolls adults (≥18 years) undergoing cardiac surgery with extracorporeal circulation (valve procedures or CABG) and uses intraoperative SedLine® processed EEG (PSi) together with cerebral NIRS monitoring. Eligible patients must have a preoperative MoCA ≥20 and ASA class II–IV, while those with prior stroke, suspected dementia, preoperative encephalopathy, dialysis-dependent renal failure, or oxygen-dependent chronic respiratory failure are excluded. The approach compares management guided by combined PSi+NIRS monitoring versus standard intraoperative care to see if targeting deep anesthesia and cerebral desaturation reduces rates of postoperative cognitive disorders, with a planned secondary analysis for patients aged 65 and older. Cognitive testing is performed before and after surgery to measure postoperative cognitive outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Elective or relatively emergency surgery for valve surgery (pulmonary or tricuspid valves) or coronary artery bypass grafting (CABG)
* Preoperative cognitive assessment MoCA ≥ 20 (during the preoperative consultation if applicable or on day 1)
* ASA score II to IV

Exclusion Criteria:

* History of sequelae of stroke
* Diagnosis or strong suspicion of dementia (according to DSM-V criteria).
* Preoperative encephalopathy
* Severe chronic renal failure requiring dialysis
* Patients with chronic respiratory failure who are oxygen-dependent

Where it's running

• CHU Brugmann
  Brussels, Belgium Recruiting

Study contacts

• Principal investigator: Aimane MENIOUI, MD — CHU Brugmann
• Study coordinator: Aimane MENIOUI, MD
• Email: aimane.menioui@chu-brugmann.be
• Phone: 3224754103

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.