Combined intra‑articular and peri‑articular PRP injections for chronic knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with medial knee osteoarthritis (Kellgren‑Lawrence grade 2–3) receive ultrasound-guided platelet-rich plasma (PRP) injections either into the joint alone or combined with peri‑articular injections targeting structures such as the MCL and pes anserinus. The trial compares pain, physical function, activities of daily living, and structural ultrasound measures including medial collateral ligament thickness and distal femoral cartilage thickness between the two approaches. Eligibility emphasizes persistent medial knee pain (VAS ≥4) after at least three months of conservative care and excludes recent knee injections, prior knee surgery, inflammatory arthropathies, active infection, or significant bleeding disorders. Outcomes will determine whether targeting both intra‑articular and peri‑articular tissues yields greater symptomatic and structural benefit than intra‑articular PRP alone.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Age between 40 and 65 years.
* Patients with significant medial knee pain who have not responded to conservative treatment for at least 3 months.
* Patients diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) criteria and with Kellgren-Lawrence grade 2 or 3 radiographic osteoarthritis.
* Intact cognitive function.
* Willingness to participate in the study and provide signed informed consent.
* Visual Analog Scale (VAS) score of 4 or higher.

Exclusion Criteria

* History of previous knee trauma or surgery.
* Physical therapy, intra-articular steroid, or hyaluronic acid injections in the knee within the last 3 months.
* Active oncological diseases.
* Local infection, sepsis, wounds, or scars in the injection area.
* Systemic infections, hepatitis, or immunosuppression.
* Bleeding diathesis or irregular International Normalized Ratio (INR) due to oral warfarin use.
* Inflammatory arthropathies.
* Uncontrolled hypertension, uncontrolled diabetes mellitus, decompensated heart failure, coronary artery disease, or asthma.
* Suspected or confirmed pregnancy.
* Use of corticosteroids or opioids.
* Anemia.
* Body mass index (BMI) greater than 35.
* Allergy to citrate.
* Use of nonsteroidal anti-inflammatory drugs (NSAIDs) within the last week that may affect platelet function analyzer-100 (PFA-100) activity.
* Physical examination findings suggestive of patellar retinaculum, meniscus, or cruciate ligament injury.
* General health impairment or lack of cooperation.
* Refusal to participate in the study.

Where it's running

• Ankara Bilkent City Hospital, Physical Therapy and Rehabilitation Hospital
  Ankara, Çankaya, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Rıdvan E ÇELİK
• Email: ridvancelik94@gmail.com
• Phone: +905078414386

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.