Combination therapy for advanced lung cancer with EGFR mutations

A Phase II, Multicenter Study to Assess the Safety, Tolerability and Anti-tumor Efficacy of DZD9008 in Combination With AZD4205 in Standard Treatment Failed Non-Small Cell Lung Cancer (NSCLC) Patients With EGFR Mutations

This study is testing a new combination treatment for advanced lung cancer in patients with EGFR mutations who haven't had success with standard therapies.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 90 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Dizal Pharmaceuticals (Industry-sponsored)
• Drugs / interventions: chemotherapy, immunotherapy, radiation
• Locations: 4 sites (Guangzhou, Guangdong and 3 other locations)
• Trial ID: NCT06295432 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the safety and efficacy of DZD9008 in combination with AZD4205 for patients with advanced non-small cell lung cancer (NSCLC) who have EGFR mutations and have not responded to standard treatments. The study aims to provide a new therapeutic option for this patient population by assessing the effects of the combination therapy. Participants will be closely monitored for their response to treatment and any potential side effects.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with confirmed advanced NSCLC and EGFR mutations who have experienced treatment failure with standard therapies.

Not a fit: Patients with untreated brain metastases or those requiring corticosteroid treatment for neurological symptoms may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could offer a new effective option for patients with advanced NSCLC who have limited alternatives after standard therapies.

How similar studies have performed: Other studies have shown promise with similar combination therapies in treating NSCLC, indicating potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

1. Patients must be able to understand the nature of the trial and provide a signed and dated informed consent form prior to screening.
2. Aged at least 18 years old when sign ICF.
3. Histological or cytological confirmed locally advanced or metastatic NSCLC.
4. Patients must exhibit Eastern Cooperative Oncology Group (ECOG) performance status 0 - 1 at ICF signature with no deterioration over the previous 2 weeks.
5. Predicted life expectancy ≥ 12 weeks.
6. Patients with brain metastasis (BM) can only be enrolled under the condition that BM is previously treated and stable e.g. no evidence of progression for at least 2 weeks after CNS-directed treatment as ascertained by clinical examination and brain imaging (magnetic resonance image \[MRI\] or computed tomography \[CT\] scan) during the screening period), neurologically asymptomatic and not require corticosteroid treatment.
7. Adequate organ system functions, as outlined below

   * Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
   * Absolute lymphocyte count ≥ 0.8 x 109/L
   * Platelets ≥ 100 x 109/L
   * Hemoglobin ≥ 9 g/dL
   * Total bilirubin ≤ 1.5 x ULN if no liver metastases or ≤ 3 x ULN in the presence of documented Gilbert's Syndrome (unconjugated hyperbilirubinemia) or liver metastases
   * Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 x ULN if no liver involvement or ≤ 5 x ULN with liver involvement
   * Creatinine ≤ 1.5 x ULN, or measured creatinine clearance ≥ 50 mL/min as calculated by the Cockcroft-Gault method
   * International normalized ratio (INR) ≤ 1.5 x ULN and activated partial thromboplastin time (APTT) ≤ 1.5 x ULN;
   * Serum amylase ≤ 1.5 x ULN and serum lipase ≤ 1.5 x ULN
8. Male subjects with a female partner who intend to have children should use barrier contraception (e.g. condom) during their participation in the clinical study until 6 months after the last dose. Male subjects should not donate sperm during the clinical study until 6 months after the last dose. If the male subject has fertility requirements, it is recommended that sperm be frozen prior to the start of the clinical study.
9. Female subjects should use contraception at screening until 6 weeks after the last dose of DZD9008 or 3 months after the last dose of AZD4205, whichever is later, should not be breastfeeding and should have a negative pregnancy test (blood or urine β-HCG) at the time of screening.

Part A specific inclusion criteria:

1. Subjects should harbour any type of EGFR mutation.
2. Subjects should have progressed on, or be intolerant of prior standard systemic therapy for metastatic/locally advanced disease.

Part B specific inclusion criteria:

1. Subjects must have documented EGFR sensitizing mutation from a local certified laboratory.
2. Subjects should have progressed on, or be intolerant of prior standard systemic therapy for metastatic/locally advanced disease.
3. Patient must have measurable disease according to RECIST 1.1: At least one lesion, not previously irradiated, that can be accurately measured at baseline as ≥ 10 mm in the longest diameter (except lymph nodes which must have short axis ≥15 mm) with computed tomography (CT) or magnetic resonance imaging (MRI) and which is suitable for repeated measurement.
4. Agree and be willing to provide an adequate amount of the required tumor tissue for exploratory studies.

Exclusion Criteria:

1. Treatment with any of the followings:

   * Prior treatment with any onco-immunotherapy (e.g. PD-1) within 4 weeks before the first administration of IP.
   * Any cytotoxic chemotherapy, or other anticancer drugs from a previous treatment regimen within 2 weeks before the first administration of IP.
   * Radiotherapy within 2 weeks of the first dose or have not recovered from radiotherapy-related toxicity May receive palliative radiotherapy other than chest and brain, stereotactic radiosurgery and stereotactic body radiation therapy within 1 week prior to first dose a limited field of radiation for palliation within 1 week of the first administration of IP.
   * Patients currently receiving (or unable to stop using) medications known to be potent inhibitors or inducers of CYP3A or herbal supplements within 2 weeks before the first administration of IP.
   * Patients should avoid eating food known to be inhibitors of CYP3A such as grapefruit and Seville oranges (and other products containing these fruits, e.g., grapefruit juice or marmalade) within 2 weeks before the first administration of IP and 2 weeks after the therapy.
   * Drugs that prolong the QT interval need to be discontinued before the start of IP
   * Major surgery (excluding biopsy) within 4 weeks before the first administration of IP, or expect to have major surgery during study.
   * Treatment with any investigational drug (or unable to stop using) within 4 weeks before the first administration of IP
2. Spinal cord compression or leptomeningeal metastasis.
3. Prior malignancy within 2 years requires active treatment, except for adequately treated basal cell skin carcinoma, in situ cervical carcinoma, or other cancer type which has been disease free for \> 2 years with life expectancy \>2 years
4. Any unresolved toxicities from prior therapy greater than CTCAE grade 1 at the time of starting IP with the exception of alopecia.
5. History of stroke or intracranial haemorrhage within 6 months before the first administration of IP.
6. As judged by the investigator, any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension and active bleeding diatheses (e.g., hemophilia, Von Willebrand disease).
7. Presence of persistent or active infection, including but not limited to:

   * Active or latent tuberculosis
   * Active herpes simplex, herpes zoster infection
   * COVID-19
   * active HBV, HCV, HIV infection
8. Any of the following cardiac abnormal and disease:

   * resting corrected QT interval (QTc) \> 470 msec
   * Any clinically significant abnormalities in rhythm, conduction or morphology of resting ECG, e.g., complete left bundle branch block, third degree heart block, and second-degree heart block, PR interval \> 250 msec
   * Any factors that increase the risk of QTc prolongation, such as heart failure, hypokalemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age in first degree relatives or any concomitant medication known to prolong the QT interval
   * Prior history of atrial fibrillation except prior drug treatment related and recovered
   * Prior history of myocardial infarction, congestive heart failure, arrhythmias that are poorly controlled by medication
   * LVEF \< 55% accessed by ECHO
9. Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease, immunotherapy-induced immune pneumonitis.
10. Significant pulmonary function impairment (i.e. pulmonary function test showing FEV1 and DLCO \< 60% of expected values).
11. Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of IP.
12. Receiving live vaccines within 2 weeks before the first administration of IP.
13. Women who are pregnant or breast feeding.
14. Involvement in the planning and conduct of the study (applies to Dizal staff or staff at the study site).
15. Judgment by the investigator that the patient should not participate in the study if the patient is unlikely to comply with study procedures, restrictions and requirements.

Where this trial is running

Guangzhou, Guangdong and 3 other locations

• Guangdong Provincial People'S Hospital — Guangzhou, Guangdong, China (Recruiting)
• Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology — Wuhan, China (Completed)
• The First Affiliated Hospital of Xi'an Jiaotong University — Xi'an, China (Completed)
• Henan Cancer Hospital — Zhengzhou, China (Recruiting)

Study contacts

• Principal investigator: Zhen Wang — Guangdong Provincial People's Hospital
• Study coordinator: Xindi Wang

Conditions Non-small Cell Lung Cancer