Collection and distribution of blood components from healthy donors for research use
Collection and Distribution of Blood Components From Healthy Donors for In Vitro Research Use
This study is about collecting blood from healthy volunteers to help researchers at NIH and FDA with their lab work.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Trial ID | NCT00001846 on ClinicalTrials.gov |
What this trial studies
This protocol facilitates the collection and processing of blood components from healthy volunteer donors for distribution to NIH and FDA researchers for in vitro laboratory use. Donors are recruited based on specific eligibility criteria and compensated for their participation. The donation process involves standard phlebotomy and apheresis techniques, with careful monitoring of donor safety and informed consent procedures. Blood components are assigned unique product numbers to ensure confidentiality and traceability.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 18 and older who meet specific eligibility criteria for blood donation.
Not a fit: Patients with known heart, lung, or kidney diseases, as well as those with bleeding disorders or a history of high-risk activities for HIV exposure, may not benefit from this study.
Why it matters
Potential benefit: If successful, this initiative could enhance the availability of high-quality blood samples for critical research, potentially leading to advancements in medical science.
How similar studies have performed: Other studies utilizing similar approaches for blood component collection have shown success in supporting various research initiatives.
Eligibility criteria
Show full inclusion / exclusion criteria
* ELIGIBILITY CRITERIA: Donors must meet the eligibility criteria for volunteer blood donation, defined in the Code of Federal Regulations 21 CFR 640, and AABB Standards as modified in the 2007 FDA/CBER Guidance Document: Eligibility Criteria for Donors of Human Cells, Tissues, and Cellular and Tissue-Based Products, with the exception of foreign travel history and other conditions, as noted below: * Ability of subject to understand, ask questions, and the willingness to provide written informed consent * Age greater than or equal to 18 years * Weight greater than 110 pounds * Female subjects should not be pregnant * No known heart, lung, kidney disease, or bleeding disorders * No history of sickle cell disease * No history of engaging in high-risk activities for exposure to the AIDS virus, as defined in the AABB Donor Education Materials distributed to all donors. Deferral periods for high-risk activities (MSM, IV drug use or receipt of money or drugs in exchange for sex) will not exceed the corresponding deferral period as defined for allogeneic blood donors. * No history of malaria in the past 12 months * Donors who have a family history of CJD, donors who have undergone tattooing or body piercing, donors who have received a graft such as bone, skin or dura mater, donors who are taking finasteride or retinoids, and donors who have had sexual contact within the past 12 months with a person who has symptomatic hepatitis C infection or donors who have lived with a person who has hepatitis in the last 12 months, are similarly eligible for research-use only donations on this protocol. * Donors who have traveled to Europe, Africa, Asia, and areas of South America, who are rendered ineligible for allogeneic donation due to malarial risk, Zika risk and vCJD risk, are eligible for research donations * Donors with a history of repeat false positive HTLV I/II, who are rendered ineligible for allogeneic donation, are eligible for research donations. * Donors with a positive antibody to hepatitis B core antigen (anti-HBc) only, without other positive infectious disease markers,are eligible for research donations. * Donors with HLA antibodies are eligible for research donations * Donors who have received an experimental drug, agent, or vaccine, and who are referred for a research blood, plasma or leukocyte collection, specifically because they were given this drug, agent, or vaccine, are acceptable only if their research product is collected for use by the PI who administered the experimental drug, agent, or vaccine. Otherwise, they are deferred for one year after receiving an experimental drug, agent, or vaccine. * Donors who have received a xenotransplant are eligible for research donations. * Granulocyte donors may not receive dexamethasone if they have poorly controlled hypertension or diabetes, or if they have a history of cataracts. Hetastarch (also known as hydroxyethyl starch or "HES") and dexamethasone may elevate blood pressure and raise blood glucose levels, and repetitive steroid administration may increase the risk of posterior subcapsular cataract formation or progression. * Granulocyte donors must have an estimated glomerular filtration (eGFR) rate of \> 45ml/min/1.73m\^2. * Granulocyte donors may not receive filgrastim if they have a history or symptoms of coronary heart disease. Investigators are informed that eligibility standards for research donors differ from those for transfusion donors through an electronic "User Agreement" which they electronically sign when they register to receive blood components on this protocol.
Where this trial is running
Bethesda, Maryland
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Leonard N Chen, M.D. — National Institutes of Health Clinical Center (CC)
- Study coordinator: Sandra Z Amamoo-Kakra
- Email: sandra.amamoo-kakra@nih.gov
- Phone: (301) 402-0757
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.