Collecting tissue samples to understand solid tumors better
Official title: Tissue Collection Framework To Improve Outcomes In Solid Tumours
Run by Queen Mary University of London · NCT03572192 · Data updated 2026-11-12
This study is collecting tissue samples from cancer patients to see how solid tumors work and why some treatments don't always work, with the hope of finding better therapies in the future.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | Queen Mary University of London Academic / other |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | September 2013 |
| Main results expected | August 2043 |
| Study ends | August 2043 |
| Registry record updated | November 18, 2025 |
| Trial ID | NCT03572192 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old who have been diagnosed with a solid tumor and are receiving clinical management at Barts Health NHS Trust.
✕Probably not a fit
Patients with co-existing medical conditions that significantly increase participation risks or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to collect cancer and normal tissue specimens from patients diagnosed with solid tumors to analyze them using advanced molecular profiling technologies. By examining these samples, researchers hope to uncover the mechanisms behind cancer cell metastasis and drug resistance, which are not well understood. The study will involve approximately 320,000 patients diagnosed with cancer in the UK each year, focusing on the genetic and molecular factors that contribute to treatment outcomes. Insights gained from this research could lead to the development of improved cancer therapies and predictive tests for treatment tolerance.
Why it matters
Potential benefit: If successful, this study could lead to better cancer treatments that prevent drug resistance and improve patient survival rates.
How similar studies have gone: Other studies utilizing molecular profiling techniques have shown promise in understanding cancer mechanisms, suggesting that this approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Male and female patients over the age of 18 years who have been diagnosed with a solid tumour and who are seen at the Barts Health NHS Trust for clinical management of their tumour. 2. Male or female more than 18 years of age 3. Able to participate in the study. 4. Able to give informed consent. 5. Patients enrolled into other clinical trials may be included into this study Exclusion Criteria 1. Any co-existing medical condition that in the Investigator's judgement will substantially increase the risk associated with the patient's participation in the study 2. Psychiatric disorders or altered mental status precluding understanding of the informed consent process and/or completion of the necessary studies 3. Physical or mental health issues that preclude them from participation
Where it's running
-
St Bartholomew's Hospital
London, United Kingdom Recruiting
Study contacts
- Study coordinator: Thomas Powles
- Email: bci-orchidtrials@qmul.ac.uk
- Phone: 0207 882 8762
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Testing how well different doses of BI 4060107 are tolerated in adults with unresectable advanced solid tumours
This trial tests different dose levels of BI 4060107 to see which dose patients with advanced solid tumours can tolerate.
-
Testing different dose levels of BI 3822971 in adults with advanced solid tumors
A single-arm early-phase trial is testing how well BI 3822971 is tolerated in adults with advanced or metastatic solid cancers who have exhausted standard therapies.
-
GEN1119 in people with solid tumors
This phase 1 trial tests GEN1119 in adults with solid cancers to see if it is safe and how it behaves in the body and may show signs of activity against tumors.
-
AZD4956 alone or with saruparib for advanced HRR-deficient solid tumors
This will test AZD4956 by itself and together with saruparib in people who have advanced or metastatic solid tumors with homologous recombination repair defects.
-
Subcutaneous durvalumab plus hyaluronidase dose-finding and safety for solid tumors
This study will test whether a subcutaneous (under-the-skin) injection of durvalumab with hyaluronidase gives similar blood levels and is safe for people with certain advanced solid tumors, including unresectable liver cancer and specific forms of lung cancer.
-
Different doses of BI 3810944 for adults with advanced solid tumors
This trial tests different doses of the experimental drug BI 3810944 to see if adults with advanced solid tumours, including melanoma, who have not had success with standard treatments can tolerate it and might benefit.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.