Collecting samples from healthy volunteers for analysis of blood disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to create a comprehensive database of biospecimens from healthy volunteers to better understand myelodysplastic syndromes (MDS) and their progression to acute myeloid leukemia (AML). Participants aged 18 and older will undergo screening and provide various samples, including blood, bone marrow, saliva, stool, and skin biopsies. The goal is to compare these samples with those from individuals with MDS to elucidate disease mechanisms and develop novel therapeutic strategies.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:
* Age \>= 18 years old
* Healthy volunteers; the following confirmed by the Principal Investigator or designees based on recent (within 3 months before study intervention(s))
* medical history
* physical exam
* complete blood count (CBC) within the normal reference range per the reporting clinical laboratory, established published literature and reports, or as deemed acceptable by the medical team based on the age and condition of the volunteer consistent with established clinical standards.
* The ability of the participant to understand and the willingness to sign a written consent document.

EXCLUSION CRITERIA:

\- Active illnesses, immunodeficiency, history of opportunistic infection, autoimmune disease, history of or active malignancy, prior organ, bone marrow, or peripheral blood stem cell transplant or antibiotic treatment within 3 months before study intervention(s).

Note: participants with non-melanoma skin cancer or carcinoma in situ of the cervix or breast are eligible.

* Current immunosuppressive medication.
* Any one of the following symptoms as declared by the participant at least one day per week within 3 months before study intervention(s) (Rome IV criteria \[36\])
* Diarrhea characterized as frequent (\>2) loose stools
* Constipation defined as \< 3 spontaneous bowel movements per week
* Bloating and/or distention
* Abdominal pain.
* Participants with a history of the human immunodeficiency virus (HIV), hepatitis C (HCV), or hepatitis B (HBV) as confirmed by a seropositive blood test.
* Pregnancy confirmed with beta-Human Chorionic Gonadotropin (Beta-HCG) serum or urine pregnancy test performed in women of childbearing potential at screening.
* Breastfeeding participants.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Kathy L McGraw, Ph.D. — National Cancer Institute (NCI)
• Study coordinator: Danielle F Pinkiert, R.N.
• Email: danielle.pinkiert@nih.gov
• Phone: (240) 858-7566

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Age-stratified conditioning regimens to improve outcomes in haploidentical stem cell transplant for myelodysplastic syndrome

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• Brain network changes in adults with anemia measured by fNIRS

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  Recruiting Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT07578675

• Cord blood transplant for children and young adults with blood cancers.

  This study will test whether a cord blood transplant given as a first or second transplant can help children and young adults with leukemia, myelodysplasia, or lymphoma who lack a matched donor.

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• Reduced-intensity donor stem cell transplant with treosulfan/fludarabine and post-transplant cyclophosphamide for leukemia and MDS

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• Electronic mindfulness-based music therapy for patients receiving stem cell transplantation

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.