Collecting pancreatic juice using vinegar and endoscopic ultrasound
Vinegar-induced Collection of Duodenal Pancreatic Juice Via Endoscopic Ultrasound
NA · Peking Union Medical College Hospital · NCT05617872
This study is testing if using vinegar during an ultrasound can help collect pancreatic juice from patients suspected of having pancreatic cancer to improve diagnosis.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Peking Union Medical College Hospital (other) |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT05617872 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to assess the feasibility of collecting pancreatic juice through duodenal aspiration using endoscopic ultrasound (EUS) after infusing vinegar in patients suspected of having pancreatic cancer. Participants will undergo EUS-FNA, during which varying amounts of vinegar will be infused into the duodenum, and pancreatic juice will be collected via suction at different time intervals. The study will evaluate the quantity and molecular markers of the collected pancreatic juice to determine optimal conditions for collection. The goal is to improve diagnostic methods for pancreatic cancer.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with imaging-confirmed pancreatic masses and a diagnosis of suspected pancreatic cancer requiring EUS-FNA.
Not a fit: Patients who do not have imaging features supporting suspected pancreatic cancer or those who are unsuitable for EUS-FNA will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance the diagnostic accuracy for pancreatic cancer by enabling better molecular marker testing.
How similar studies have performed: While this specific approach is novel, similar studies using endoscopic techniques for pancreatic juice collection have shown promise in improving diagnostic capabilities.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18 years old or older * Diagnosis: CT, MRI, transabdominal ultrasound or other imaging examinations showed a pancreatic mass, and 3 endoscopists agreed on the diagnosis of suspected pancreatic cancer * EUS-FNA is required to perform further treatment strategy * The patient can understand the study protocol, is willing to participate in the study and can provide written informed consent Exclusion Criteria: * The patient's clinical and imaging features do not support the diagnosis of suspected pancreatic cancer, judged by 3 endoscopists * The patient refuses to have EUS-FNA * The patient is unsuitable for EUS-FNA because of his/her general condition, or contraindicated for anesthesia * The patient's imaging suggests severe pancreatic duct obstruction * The patient cannot understand the conditions and objectives of this study, or refuse to participate in the study
Where this trial is running
Beijing, Beijing
- Peking Union Medical College Hospital — Beijing, Beijing, China (RECRUITING)
Study contacts
- Principal investigator: Xi Wu, M.D. — Peking Union Medical College Hospital
- Study coordinator: Wen Shi, M.D.
- Email: ysfn_2005@126.com
- Phone: +8613699256758
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pancreatic Cancer, pancreatic cancer, Endoscopic ultrasound, pancreatic juice