Collecting data on COPD exacerbations in hospitalized patients
An International Multi-centre Prospective Cohort Study in Patients Hospitalized for an Acute Exacerbation of COPD
This study is collecting health information and samples from 1,000 patients hospitalized for COPD flare-ups to help improve future treatments and understanding of the condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | KU Leuven Academic / other |
| Locations | 18 sites (Linz and 17 other locations) |
| Trial ID | NCT05008081 on ClinicalTrials.gov |
What this trial studies
The CATALINA study is a prospective cohort study aimed at gathering standardized clinical data and biological samples from 1000 patients hospitalized for acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD). Conducted across 20 centers in Europe, the study involves multiple scheduled visits during hospitalization and outpatient follow-ups over a year. The goal is to create a comprehensive biobank and patient data repository to support future clinical trials and prognostic tools for COPD exacerbations.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with a confirmed diagnosis of COPD who are currently hospitalized for an acute exacerbation.
Not a fit: Patients who are not requiring treatment with systemic corticosteroids or antibiotics for their exacerbation, or those with a confirmed COVID-19 infection, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding and management of COPD exacerbations, leading to improved patient outcomes.
How similar studies have performed: Previous studies have shown success in similar approaches to collecting longitudinal data in COPD, indicating a promising avenue for this research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years and older * Established diagnosis of COPD by medical doctor (based on clinical history OR pulmonary function test with an FEV1/FVC \< 0.7) * Current hospitalization with suspicion of an acute exacerbation of COPD (AECOPD) * Inclusion within 48 hours post hospital admission * Voluntary written informed consent of the participant or his/her representative obtained prior to any study procedure Exclusion Criteria: * Patients unwilling or unable to comply with study procedures * Patients not requiring treatment with systemic corticosteroids, antibiotics or both as a minimum therapy for the index AECOPD * Patients with a confirmed positive test result for COVID19, or those highly suspected based on clinical examination
Where this trial is running
Linz and 17 other locations
- Kepler University Hospital — Linz, Austria (Recruiting)
- CHU St-Pierre Brussels — Brussels, Belgium (Recruiting)
- UZ Leuven — Leuven, Belgium (Recruiting)
- CHU UCL Namur Site Godinne — Yvoir, Belgium (Recruiting)
- CHU de Lille — Lille, France (Not_yet_recruiting)
- Cochin Hospital — Paris, France (Not_yet_recruiting)
- LungenClinic — Großhansdorf, Germany (Recruiting)
- Klinikum Itzehoe — Itzehoe, Germany (Recruiting)
- University Medical Centre of Gießen & Marburg — Marburg, Germany (Not_yet_recruiting)
- University Hospital of Ferrara — Ferrara, Italy (Not_yet_recruiting)
- UMC Groningen — Groningen, Netherlands (Not_yet_recruiting)
- Maastricht University Medical Hospital — Maastricht, Netherlands (Not_yet_recruiting)
- Hospital Clinic de Barcelona — Barcelona, Spain (Not_yet_recruiting)
- Sahlgrenska University Hospital — Gothenburg, Sweden (Recruiting)
- Glenfield Hospital — Leicester, United Kingdom (Not_yet_recruiting)
- Guy's Saint Thomas — London, United Kingdom (Not_yet_recruiting)
- Royal Brompton Hospital — London, United Kingdom (Active_not_recruiting)
- Churchil Hospital — Oxford, United Kingdom (Not_yet_recruiting)
Study contacts
- Study coordinator: Kristina Vermeersch, PhD
- Email: kristina.vermeersch@kuleuven.be
- Phone: 016342284
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.