Collecting blood and tissue samples from patients with primary liver cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to collect blood and tissue samples, along with clinical data, from patients diagnosed with primary liver cancer, specifically hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Patients undergoing systemic therapy, surgical resection, or liver biopsy will be involved in the study, which will systematically gather and store samples over three years. Blood samples will be drawn at various points during therapy, while tissue samples will be obtained from surgeries or biopsies when not needed for diagnostics. The goal is to support translational research for developing new therapies for this growing health challenge.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Primary liver cancer (hepatocellular carcinoma or intrahepatic cholangiocarcinoma)

Signed informed consent

Patient eligible to start first-line systemic therapy

Patient eligible for surgical resection

Exclusion Criteria:

Concurrent conditions with a life expectancy of less than 12 months

Autoimmune or chronic inflammatory diseases

Substance abuse dependency

Other active extrahepatic malignancies or those treated within the last 3 years, except for the following exceptions:

Tumors resected with curative intent and with no evidence of disease recurrence for \>3 years prior to signing the informed consent, considered at low risk of recurrence

Adequately resected non-melanoma skin cancers or lentigo maligna with no evidence of metastasis

Adequately treated carcinoma in situ of the cervix with no evidence of recurrence

Prostatic intraepithelial neoplasia with no evidence of infiltrative disease

Adequately treated non-invasive papillary urothelial tumors or urothelial carcinoma in situ

HIV infection

Lack of patient cooperation or failure to sign the informed consent

Where it's running

• Fondazione IRCCS Policlinico San Matteo di Pavia
  Pavia, Pavia, Italy Recruiting

Study contacts

• Study coordinator: Mario Mondelli, MD
• Email: mario.mondelli@unipv.it
• Phone: 0382501808

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.