Collavant n2 for exercise-related knee discomfort in active men

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, placebo-controlled parallel study enrolling 80 healthy amateur male runners aged 40–65 who report exercise-induced knee discomfort. Participants are randomized 1:1 to receive 40 mg/day Collavant® n2 or placebo for 24 weeks with assessments at baseline, 12 weeks, and 24 weeks. The primary outcome is change in joint discomfort, with secondary measures including joint function, physical performance, perceived exertion, pain before exercise, time to pain recovery, and markers of joint inflammation. Safety and tolerability are monitored throughout via adverse event reporting, vitals, physical exams, laboratory tests, and quality-of-life measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy physically active male adults (amateur runners) with exercise-induced joint discomfort, aged between 40 and 65 years
* Activity level: Amateur runners who train regularly a minimum of 150 minutes per week, divided into 2 or more sessions per week during at least 3 months. Principally, subjects training for popular running events of 10 Kms.
* Joint discomfort after activity: Self-reports target knee discomfort after training by a score of at least 20 mm VAS at screening. Discomfort persistent for at least 2w.
* Be willing to refrain from starting any new dietary supplements during the entire study that have any underlying joint benefits (collagen, glucosamine, chondroitin, MSM, Hyaluronic Acid, Turmeric, Natural Eggshell Membrane, Omega-3 fatty acids, PEA, Boswellia,..). If any of these supplements (except collagen) or any other dietary supplement has been taken consistently for at least 6 months prior to enrollment, participants should maintain the same stable intake pattern throughout the 24 week study period.
* Have individual devices to monitor training with GPS
* Sign informed consent

Exclusion Criteria:

* Diagnostic of knee osteoarthritis or any pathology or surgical intervention associated with the knee.
* Hypersensitivity to any component of the supplement or the placebo
* Chronic treatment with analgesic or anti-inflammatory (NSAIDs and corticosteroids families) drugs
* Treatment with any type of collagen supplement
* Treatment with probiotics or antibiotics
* Inability to train for the next 24 weeks
* Follow a vegan diet

Where it's running

• Universidad Politecnica de Madrid
  Madrid, Madrid, Spain Recruiting

Study contacts

• Principal investigator: Marcela González-Gross, Professor — Universidad Politecnica de Madrid
• Study coordinator: Mónica García-López, Doctor
• Email: monicagarcia@bioiberica.com
• Phone: +34 93 765 03 90

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Two hair supplements for men with androgenic alopecia

  This study tests two daily hair supplement formulations against placebo to see if they improve hair growth and perceived hair quality in men with mild to moderate androgenetic alopecia over 84 days.

  Recruiting at 6 sites Activ'inside · Rende, Cosenza and 5 other locations · NCT07806474

• MF1: a first-in-human test in healthy men and people with Parkinson's disease

  This early study tests MF1 to see if it is safe and how it behaves in the body, first in healthy Japanese men and then in people with Parkinson's disease- related symptoms.

  Recruiting Phase 1 University of Shizuoka · Sumida-ku, Tokyo · NCT07666022

• Biphasic IVM for POSEIDON Group 1 in young women with poor response

  This trial tests whether a two-step in vitro maturation process can help young women with normal ovarian reserve who retrieve too few eggs after standard stimulation.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City, Hồ Chí Minh · NCT07632300

• Olive oil extract for improving knee comfort and function

  This will test whether taking an olive oil extract every day for six weeks helps reduce knee pain and improve knee function in adults 40–75 who have ongoing knee discomfort.

  Recruiting Applied Food Sciences Inc. · San Francisco, California · NCT07514013

• Oxytocin's effects on emotional processing and delivery routes

  This test will see if intranasal oxytocin changes how healthy adult men process emotions and whether using a nasal vasoconstrictor to block peripheral uptake alters those effects.

  Recruiting University of Electronic Science and Technology of China · Chengdu, Sichuan · NCT07425938

• Single-ascending dose HEC-151 injection in healthy adult men

  This trial will test a single subcutaneous dose of HEC-151 in healthy men aged 18–45 to see if it is safe, how the body handles it (PK/PD), and whether it triggers immune responses.

  Recruiting Phase 1 Sunshine Lake Pharma Co., Ltd. · Chongqing, Bishan and 1 other locations · NCT07376200

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.