Collagen peptide supplements to improve connective tissue remodeling, wound healing, and recovery after total knee replacement
Official title: Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA)
Run by University of Arkansas · NCT05823727 · Data updated 2026-11-12
This trial will try daily collagen peptide supplements versus placebo in people 50–75 having total knee replacement for osteoarthritis to see if recovery, wound healing, and knee function improve.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years to 75 Years |
| Sex | All |
| Enrollment | 44 (estimated) |
| Sponsor | University of Arkansas Academic / other |
| Locations | 1 site (Little Rock, Arkansas) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | June 1, 2027 |
| Study ends | June 1, 2027 |
| Registry record updated | May 27, 2026 |
| Trial ID | NCT05823727 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 50–75 with primary knee osteoarthritis, BMI 20.0–39.9 kg/m2, scheduled for TKA at UAMS and able to attend follow-up visits in Little Rock (postmenopausal females without recent hormone therapy).
✕Probably not a fit
Patients with prior serious knee injury or ACL surgery on the operative knee, non-postmenopausal females, recent hormone therapy, active blood-borne infections, or those having TKA outside UAMS are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized interventional study enrolls adults scheduled for total knee arthroplasty (TKA) at UAMS and compares collagen peptide supplementation (SOLUGEL) to placebo with baseline and 24-week follow-up visits. Participants provide electronic consent via REDCap, are randomized, and undergo clinical outcome measures including KOOS, VR-12, POMS, physical activity and dietary logs, and DXA scans. During surgery the PI collects tissue samples (ACL fragments, synovial fluid, bone fragments) and blood for laboratory analysis of connective tissue remodeling and wound-healing markers. The protocol focuses on functional outcomes and biological measures of tissue repair to link supplementation with clinical recovery after TKA.
Why it matters
Potential benefit: If successful, patients could experience faster wound healing, stronger connective tissue, and better knee function after TKA.
How similar studies have gone: Some smaller studies have reported benefits of collagen peptides for connective tissues and joint symptoms, but applying them to improve wound healing and tissue remodeling after TKA is largely novel and not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males and Females, 50 to 75 years old * With a body mass index of 20.0 to 39.9 kg/m2 * Diagnosed with primary osteoarthritis * Scheduled for a TKA at UAMS (two months prior to surgery) at UAMS * Live near Little Rock and scheduled to attend physical therapy in Little Rock * COVID-19 negative and/or asymptomatic. Exclusion Criteria: * Previously sustained serious knee injury or surgery to ACL in TKA knee * Females not postmenopausal * Having undergone hormone replacement therapy in the last 12 months. * Active diagnosis of blood borne infectious disease
Where it's running
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University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States Recruiting
Study contacts
- Study coordinator: Shiloah Kviatkovsky
- Email: SKviatkovsky@uams.edu
- Phone: 619-677-0792
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.