Collagen fingerprinting to stratify pulmonary hypertension in chronic lung disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The investigators will analyze basement membrane and extracellular matrix remodeling by measuring non-classical collagen fragments in lung tissue and blood from patients with COPD or pulmonary fibrosis, including those undergoing lung transplantation and an outpatient cohort. Molecular patterns will be compared between patients with and without pulmonary hypertension to identify a potential circulating 'fingerprint' of disease onset and progression. The observational work uses tissue and blood sampling and targeted molecular assays to profile BM-derived biomarkers, with collaboration between the Medical University of Graz and the Medical University of Vienna. The aim is to prove the concept that these biomarkers could enable noninvasive detection and patient stratification.

Why it matters

Who can join: the full rules

Inclusion criteria:

Patients undergoing lung transplantation with COPD or PF, with or without associated PH and PAH.

\- Outpatient cohort with COPD or PF, with or without associated PH or PAH.

Exclusion criteria:

* Presence of other lung diseases
* Signs of infection, such as pneumonia, pulmonary tuberculosis, or pleural effusions.

Where it's running

• Medical University of Graz
  Graz, Styria, Austria Recruiting

Study contacts

• Study coordinator: Grazyna Kwapiszewska-Marsh, PhD
• Email: grazyna.kwapiszewska-marsh@medunigraz.at
• Phone: 004331638572918

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.