Cold snare removal for 10–20 mm pedunculated colorectal polyps
Official title: Investigation of Cold Snare Polypectomy for Removing 10-20 mm 0-Ip Colorectal Polyp: One Feasibility and Safety Study
Run by National Taiwan University Hospital · NCT07114380 · Data updated 2026-11-12
This study will see if cold snare polypectomy can completely and safely remove 10–20 mm pedunculated colorectal polyps found during colonoscopy in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 5 sites (Hsinchu and 4 other locations) |
| Status | Recruiting |
| Started | August 25, 2025 |
| Main results expected | March 2028 |
| Study ends | April 2028 |
| Registry record updated | September 19, 2025 |
| Trial ID | NCT07114380 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 20 or older undergoing colonoscopy who are found to have a 10–20 mm pedunculated colorectal polyp deemed suitable for cold snare resection.
✕Probably not a fit
People with polyps smaller than 10 mm or larger than 20 mm, non-pedunculated lesions, or those with medical contraindications to colonoscopy or polypectomy are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, multicenter, single-arm study in Taiwan will enroll about 120 adults undergoing colonoscopy who are found to have 10–20 mm pedunculated (0-Ip) colorectal polyps. Eligible polyps will be removed using cold snare polypectomy by experienced endoscopists with standard pre- and post-procedure care. Investigators will record polyp features, resection completeness by endoscopy and pathology, and immediate and delayed complications such as bleeding or perforation. Primary outcomes are technical success (complete removal) and safety (adverse event rates), with analysis to identify predictors of CSP failure.
Why it matters
Potential benefit: If successful, this could offer a safer, non‑thermal option for removing larger pedunculated polyps and lower risk of thermal-related complications.
How similar studies have gone: Cold snare polypectomy is well supported for polyps under 10 mm, but its use for 10–20 mm pedunculated lesions is relatively untested and evidence is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 20 years * Undergoing colonoscopy for any clinical indication * Found to have a 10-20 mm pedunculated colorectal polyp suitable for cold snare polypectomy Exclusion Criteria: * Age \< 20 years * Medical contraindications to colonoscopy or polypectomy (e.g., recent myocardial infarction, stroke, severe unstable cardiovascular disease, acute peritonitis, fulminant colitis, perforation, or toxic megacolon) * Inadequate bowel preparation preventing complete colonoscopy or safe polypectomy
Where it's running
-
National Taiwan University Hospital Hsin-Chu Branch
Hsinchu, Taiwan Recruiting -
National Taiwan University Hospital, Jinshan Branch
New Taipei City, Taiwan Recruiting -
National Taiwan University Cancer Center
Taipei, Taiwan Recruiting -
National Taiwan University Hospital, Bei-Hu Branch
Taipei, Taiwan Recruiting -
National Taiwan University Hospital
Taipei, Taiwan Recruiting
Study contacts
- Principal investigator: Li-Chun Chang, MD, PhD — National Taiwan University Hospital
- Study coordinator: Hsin-Yun Wu, MD
- Email: kimwu010063@gmail.com
- Phone: +886978232595
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.