Clinical trial Recruiting at 1 site Interventional Ages 18 to 80

Cold ischemia during robot-assisted partial nephrectomy

Official title: The Impact of Cold Ischemia on Recovery From Ischemia After Robot-assisted Partial Nephrectomy: A Randomized Controlled Clinical Study

Run by Sun Yat-sen University · NCT07326280 · Data updated 2026-11-12

This trial will test whether using ice around the kidney during robot-assisted partial nephrectomy helps the operated kidney recover function faster in adults with kidney cancer.

Quick facts

Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment310 (estimated)
SponsorSun Yat-sen University
Academic / other
Locations1 site (Guangzhou, Guangdong)
StatusRecruiting
StartedJanuary 1, 2024
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedJanuary 8, 2026
Trial IDNCT07326280 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18–80 with renal cell carcinoma planning robot-assisted partial nephrectomy and cleared for general anesthesia are the intended participants.

Probably not a fit

Patients who are not surgical candidates, are pregnant, have severe cardiovascular or cerebrovascular disease, or have anatomical variants like a horseshoe kidney would not be eligible and would not receive potential benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants are randomly assigned to one of two groups: robot-assisted partial nephrectomy with cold ischemia created by ice slush, or robot-assisted partial nephrectomy with standard warm ischemia. The study compares short-term renal function recovery between the two groups using standard postoperative kidney function measures. Adults aged 18–80 who are scheduled for robot-assisted partial nephrectomy and are fit for general anesthesia are eligible, while those with severe cardiovascular/cerebrovascular disease, horseshoe kidney, or pregnancy are excluded. The trial is conducted at a single center in Guangzhou, China.

Why it matters

Potential benefit: If successful, this approach could reduce ischemic injury and preserve kidney function after partial nephrectomy.

How similar studies have gone: Cold ischemia with ice slush has shown protective effects in open partial nephrectomy, but its use during robot-assisted partial nephrectomy is less well studied.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- 18 to 80 years old; 2. Intending to perform robot-assisted partial nephrectomy

Exclusion Criteria:

* Anesthesiologist assessment: Patient unsuitable for general anesthesia;
* Having severe cardiovascular and cerebrovascular diseases;
* horseshoe kidney;
* pregnant women

Where it's running

  • 651 Dongfeng Road East, Yuexiu District, Guangzhou, P.R. China Sun Yat-sen University Cancer Center;
    Guangzhou, Guangdong, China
    Recruiting

Study contacts

  • Principal investigator: Fangjian Zhou, professor — Sun Yat-sen University Cancer Center (SYSUCC)
  • Study coordinator: Fangjian Zhou, professor
  • Email: zhoufj@sysucc.org.cn
  • Phone: 020-87343865

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.