Cold ischemia during robot-assisted partial nephrectomy
The Impact of Cold Ischemia on Recovery From Ischemia After Robot-assisted Partial Nephrectomy: A Randomized Controlled Clinical Study
This trial will test whether using ice around the kidney during robot-assisted partial nephrectomy helps the operated kidney recover function faster in adults with kidney cancer.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 310 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT07326280 on ClinicalTrials.gov |
What this trial studies
Participants are randomly assigned to one of two groups: robot-assisted partial nephrectomy with cold ischemia created by ice slush, or robot-assisted partial nephrectomy with standard warm ischemia. The study compares short-term renal function recovery between the two groups using standard postoperative kidney function measures. Adults aged 18–80 who are scheduled for robot-assisted partial nephrectomy and are fit for general anesthesia are eligible, while those with severe cardiovascular/cerebrovascular disease, horseshoe kidney, or pregnancy are excluded. The trial is conducted at a single center in Guangzhou, China.
Who should consider this trial
Good fit: Adults 18–80 with renal cell carcinoma planning robot-assisted partial nephrectomy and cleared for general anesthesia are the intended participants.
Not a fit: Patients who are not surgical candidates, are pregnant, have severe cardiovascular or cerebrovascular disease, or have anatomical variants like a horseshoe kidney would not be eligible and would not receive potential benefit from this protocol.
Why it matters
Potential benefit: If successful, this approach could reduce ischemic injury and preserve kidney function after partial nephrectomy.
How similar studies have performed: Cold ischemia with ice slush has shown protective effects in open partial nephrectomy, but its use during robot-assisted partial nephrectomy is less well studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- 18 to 80 years old; 2. Intending to perform robot-assisted partial nephrectomy Exclusion Criteria: * Anesthesiologist assessment: Patient unsuitable for general anesthesia; * Having severe cardiovascular and cerebrovascular diseases; * horseshoe kidney; * pregnant women
Where this trial is running
Guangzhou, Guangdong
- 651 Dongfeng Road East, Yuexiu District, Guangzhou, P.R. China Sun Yat-sen University Cancer Center； — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Principal investigator: Fangjian Zhou, professor — Sun Yat-sen University Cancer Center (SYSUCC)
- Study coordinator: Fangjian Zhou, professor
- Email: zhoufj@sysucc.org.cn
- Phone: 020-87343865
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.