Cold ischemia during robot-assisted partial nephrectomy
Official title: The Impact of Cold Ischemia on Recovery From Ischemia After Robot-assisted Partial Nephrectomy: A Randomized Controlled Clinical Study
Run by Sun Yat-sen University · NCT07326280 · Data updated 2026-11-12
This trial will test whether using ice around the kidney during robot-assisted partial nephrectomy helps the operated kidney recover function faster in adults with kidney cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 310 (estimated) |
| Sponsor | Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | January 1, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | January 8, 2026 |
| Trial ID | NCT07326280 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–80 with renal cell carcinoma planning robot-assisted partial nephrectomy and cleared for general anesthesia are the intended participants.
✕Probably not a fit
Patients who are not surgical candidates, are pregnant, have severe cardiovascular or cerebrovascular disease, or have anatomical variants like a horseshoe kidney would not be eligible and would not receive potential benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants are randomly assigned to one of two groups: robot-assisted partial nephrectomy with cold ischemia created by ice slush, or robot-assisted partial nephrectomy with standard warm ischemia. The study compares short-term renal function recovery between the two groups using standard postoperative kidney function measures. Adults aged 18–80 who are scheduled for robot-assisted partial nephrectomy and are fit for general anesthesia are eligible, while those with severe cardiovascular/cerebrovascular disease, horseshoe kidney, or pregnancy are excluded. The trial is conducted at a single center in Guangzhou, China.
Why it matters
Potential benefit: If successful, this approach could reduce ischemic injury and preserve kidney function after partial nephrectomy.
How similar studies have gone: Cold ischemia with ice slush has shown protective effects in open partial nephrectomy, but its use during robot-assisted partial nephrectomy is less well studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- 18 to 80 years old; 2. Intending to perform robot-assisted partial nephrectomy Exclusion Criteria: * Anesthesiologist assessment: Patient unsuitable for general anesthesia; * Having severe cardiovascular and cerebrovascular diseases; * horseshoe kidney; * pregnant women
Where it's running
-
651 Dongfeng Road East, Yuexiu District, Guangzhou, P.R. China Sun Yat-sen University Cancer Center;
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Fangjian Zhou, professor — Sun Yat-sen University Cancer Center (SYSUCC)
- Study coordinator: Fangjian Zhou, professor
- Email: zhoufj@sysucc.org.cn
- Phone: 020-87343865
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.