Cohort study on the natural history of Parkinson's disease in France

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The NS-PARK cohort aims to describe the natural history of Parkinson's disease (PD) and develop patient stratification models based on the disease's pathophysiological mechanisms. Conducted across expert centers in France, the study collects standardized demographic, diagnostic, and clinical data, including motor and non-motor symptoms, which are updated at each patient visit. Blood samples are also collected for genetic testing and biobanking. This longitudinal cohort will facilitate the understanding of PD progression and support the discovery of new genetic factors influencing the disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of Parkinson's disease according to UK PD brain bak criteria
* OR diagnosis of parkinsonian syndrome: multiple system atrophy, progressive supranuclear palsy, dementia with Lewy body, or corticobasal syndrom
* OR Subjects at risk of PD defined as :

No symptom or diagnosis of Parkinson's disease nor parkinsonian syndrome, and relative to a patient with a diagosis of PD or parkinsonian syndrome, or carrier of a known mutation responsible for a genetic form of PD or patient with a diagnosis of idiopathic REEM sleep disorder or prodromal form of PD as defined by MDS criteria (Berg et al., 2015)

AND for all participants

* Affiliated to social security
* Age \> 10 years

Exclusion Criteria:

* Subject under legal protection
* Subject who do not consent to the research
* for the optional skin biopsy only: clinically significant coagulation abnormalities or anticoagulant treatment

Where it's running

• Centre 01 Paris
  Paris, France Recruiting

Study contacts

• Principal investigator: Jean Christophe MD CORVOL, PU-PH — Umrs 1127
• Study coordinator: Jean Christophe MD CORVOL, PU-PH
• Email: jean-christophe.corvol@aphp.fr
• Phone: 33 1 42 16 57 66

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.