Cohort study on relapsing-remitting multiple sclerosis using imaging and blood tests

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to establish a prospective cohort of patients with relapsing-remitting multiple sclerosis (RRMS) to better understand the disease's evolution and the effectiveness of high efficacy treatments (HET) compared to medium efficacy treatments (MET). By recruiting patients aged 18 to 55 who have not experienced a relapse for at least six months, the study will utilize magnetic resonance imaging (MRI), blood tests, and neuropsychological assessments to gather comprehensive clinical and imaging data. The goal is to confirm the long-term superiority of HET over MET while ensuring a high retention rate of participants. This research will also explore the relationship between brain atrophy and various factors affecting disease progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over 18 and under 60 years of age
* Patients with Relapsing-remitting MS without relapse for at least 6 months
* EDSS\<6 at time of inclusion

Exclusion Criteria:

* Secondary progressive MS or Primary progressive MS at time of inclusion
* Evidence of disease progression (clinical or radiological)
* Change in treatment within 6 months prior to inclusion
* Subject with a contraindication to MRI (claustrophobia, pacemaker, etc.)
* Inability to follow the follow-up planned by the study
* Pregnant or breastfeeding women
* Patient not affiliated to the social security system or not benefiting from such a system
* Adult protected by law or patient under guardianship or curatorship
* Failure to obtain written informed consent after a reflection period

Where it's running

• Neurology Department, Hopital Gui de Chauliac
  Montpellier, France Recruiting

Study contacts

• Study coordinator: Xavier AYRIGNAC, Medical Doctor
• Email: x-ayrignac@chu-montpellier.fr
• Phone: 0467337202

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.