Cognitive treatment for breast cancer survivors with cognitive impairments

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) compared to traditional cognitive rehabilitation in alleviating cognitive deficits in breast cancer survivors. The study involves a three-arm randomized design with 123 participants who will be assigned to either the UP intervention, cognitive rehabilitation, or a waitlist control group. The primary goal is to assess improvements in cognitive function, anxiety, depression, and overall quality of life among the participants over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Cancer diagnosis, stages I-III.
* Cancer type: Breast.
* Have received the last chemotherapy session in the last 6 months and a maximum of 6 years of treatment completion.
* Probable or mild to moderate cognitive impairment (score between 26 and 10 points according to the MMSE).
* Ability to be fluent in Spanish.
* Not currently participating in another clinical trial.
* Not currently receiving other psychological treatment

Exclusion Criteria:

* Men and women aged \> 70 years.
* Diagnosis of cancer, stage IV or other types of cancer.
* Last chemotherapy session \< 6 months or \> 6 years.
* No cognitive impairment (MMSE score between 30 and 27 points).
* Diagnosis of mental disorder (including substance abuse) prior to cancer diagnosis.
* Relapse in disease after chemotherapy treatment is completed.
* Neurodevelopmental Disorder Diagnosis.
* Diagnosis of diseases that affect cognitive performance such as: hypertension, cardiac diseases, epilepsy, dementias, multiple sclerosis, functional disorders (fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, post-concussion syndrome, whiplash syndrome), CNS infections (HIV, encephalitis), metabolic disorders (diabetes, B12 deficiency), obstructive sleep apnea, brain damage (stroke, TBI, CNS cancer) and use of medications / substances that interfere with cognitive function such as pregabalin, gabapentin, topiramate, antidepressants tricyclics, sodium valproate, anticholinergics, methylphenidate, typical antipsychotics.

Where it's running

• Reina Sofía University Hospital
  Córdoba, Spain Recruiting
• Hospital Universitario Reina Sofía
  Córdoba, Spain Not yet recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Exercise program for women with triple-negative breast cancer

  This study is testing whether a special exercise program can help women aged 18 to 50 with newly diagnosed triple-negative breast cancer feel better and improve their fitness during chemotherapy and immunotherapy.

  Recruiting at 2 sites Technical University of Munich · Munich, Bavaria and 1 other locations · NCT06672120

• Comparing two radiotherapy schedules for breast cancer treatment

  This study is testing two different schedules of radiotherapy for breast cancer to see which one causes fewer side effects and helps patients feel better.

  Recruiting University Hospital, Ghent · Ghent and 1 other locations · NCT06345534

• Using tart cherry juice to prevent nerve damage from chemotherapy in breast cancer patients

  This study is testing if drinking tart cherry juice can help prevent nerve damage in breast cancer patients receiving chemotherapy.

  Recruiting Phase 2 University of California, Davis · Sacramento, California · NCT06268665

• Digital program to improve health for Hispanic female cancer survivors and their daughters

  This study tests a digital program aimed at helping Hispanic female cancer survivors and their daughters improve their health habits, like exercise and diet, to see if it works well for them.

  Recruiting University of Miami · Miami, Florida · NCT05721976

• Using patient avatars to guide treatment for metastatic breast cancer

  This study is testing whether using patient avatars made from biopsy samples can help find the best treatments for people with metastatic breast cancer.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT04608357

• AI-based precision oncology clinical trial matching and registry

  This study is testing whether an AI tool can help match cancer patients with the right clinical trials based on their specific cancer details to see if it improves their chances of getting into trials and their overall outcomes.

  Recruiting at 68 sites Massive Bio, Inc. · Birmingham, Alabama and 67 other locations · NCT03452774

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.