Cognitive training games for patients with mild cognitive impairment at home
Towards the Development of a Mobile-health Technology Designed to Encourage the Use of Serious Game-based Interventions in Patients With Mild Cognitive Impairment Outside the Clinic
This study is testing if playing Neuro-World cognitive training games at home can help people with mild cognitive impairment improve their thinking skills.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 55 Years and up |
| Sex | All |
| Sponsor | University of Massachusetts, Amherst Academic / other |
| Locations | 2 sites (Amherst, Massachusetts and 1 other locations) |
| Trial ID | NCT04920123 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of Neuro-World cognitive training games in improving cognitive function among patients with mild cognitive impairment. It is designed as a cross-over randomized controlled trial involving fifty participants who will alternate between periods of using the games and periods without any cognitive therapy. Participants will self-administer the games for 30 minutes twice a week over 12 weeks, with regular phone check-ins to monitor adherence and daily activity changes. The goal is to assess whether these games can provide therapeutic benefits outside of a clinical setting.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 55 and older with mild cognitive impairment as indicated by a Montreal Cognitive Assessment score between 17 and 25.
Not a fit: Patients with significant neurological or psychiatric disorders, dementia, or severe impairments affecting tablet use may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could enhance cognitive function and daily living activities for patients with mild cognitive impairment.
How similar studies have performed: Other studies have shown promise in using game-based cognitive interventions, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Seventeen points or greater and smaller than twenty-six points on the Montreal Cognitive Assessment (MoCA) * Fifty-five years old and above * Minimal technological literacy (i.e. ability to use a tablet independently) * Having a computer for online videoconferencing-based communication (necessary for online cognitive assessments) Exclusion Criteria: * Confounding neurological and psychiatric disorders * History of traumatic brain injury * Clinically known hearing or vision impairment * Severe upper-limb motor impairments that could impact the use of mobile devices * Clinical presentations suggestive of dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, or vascular parkinsonism * Diagnosis of dementia * Major depression * Any significant upper-limb impairment that could affect tablet use * Participation in any other therapist-supervised cognitive training
Where this trial is running
Amherst, Massachusetts and 1 other locations
- University of Massachusetts, Amherst — Amherst, Massachusetts, United States (Recruiting)
- The State University of New Jersey, Rutgers — Newark, New Jersey, United States (Recruiting)
Study contacts
- Principal investigator: Sunghoon I Lee, PhD — University of Massachusetts, Amherst
- Study coordinator: Juhyeon Lee, MS
- Email: juhyeonlee@cs.umass.edu
- Phone: 413-404-4732
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.