Cognitive training for mild cognitive impairment

Repeated Advanced Cognitive Training in Mild Cognitive Impairment (The REACT MCI Study). A Randomized, Controlled Trial.

This study is testing if using a computer or iPad for brain training can help people with mild cognitive impairment slow down their memory loss.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 213 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Sorlandet Hospital HF (other gov)
• Locations: 5 sites (Arendal and 4 other locations)
• Trial ID: NCT04792528 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness and cost-efficiency of computerized cognitive training for individuals diagnosed with mild cognitive impairment (MCI). Participants will engage in repeated advanced cognitive training sessions using an iPad or computer to enhance their working memory. The study aims to determine if such interventions can delay the progression of cognitive decline associated with dementia. It is conducted across multiple centers in Norway, ensuring a diverse participant pool.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals diagnosed with mild cognitive impairment who are fluent in Norwegian and have access to a computer or iPad.

Not a fit: Patients with major psychiatric illnesses, recent strokes, or those unable to undergo MRI investigations may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a non-pharmacological intervention to slow the progression of cognitive decline in patients with mild cognitive impairment.

How similar studies have performed: Other studies have shown promise in using cognitive training for MCI, suggesting that this approach may be effective, though the specific methodology in this trial may be novel.

Eligibility criteria

Inclusion Criteria for the REACT MCI study:

* Diagnosis of MCI, based on the Mayo/winblad criteria or confirmation of current MCI status within the last 6 months before study enrollment.
* The ability to use and accessibility to an iPad or computer.
* Fluent in Norwegian.
* Spinal tap performed and results available

Exclusion Criteria for the REACT MCI study:

* Patients unable to undergo a MRI investigation based on claustrophobia or metal foreign bodies are excluded from the study.
* Major psychiatric illness and current substance abuse
* Recent stroke

Inclusion Criteria for the REACT MCI Glymphatics substudy:

* Enrollment in the REACT MCI study
* Participant allocated to Sorlandet Hospital or Oslo University Hospital

Exclusion Criteria for the REACT MCI Glymphatics substudy:

* Individuals with known allergy against contrast solutions
* Individuals with other serious allergies
* Individuals with kidney failure or glomerular filtration rate \< 30
* Individuals younger than 18 or older than 80
* Pregnant or lactating women
* For individuals \>70 years or with medications affecting kidney function the glomerular filtration rate needs to be less than week old.

Where this trial is running

Arendal and 4 other locations

• Sørlandet Sykehus Arendal — Arendal, Norway (RECRUITING)
• NKS Olaviken Alderspsykiatriske sykehus - Hukommelsesklinikk — Bergen, Norway (RECRUITING)
• N.K.S. Kløveråsen — Bodø, Norway (RECRUITING)
• Oslo Universitetssykehus Ullevål — Oslo, Norway (RECRUITING)
• St. Olavs Hospital — Trondheim, Norway (RECRUITING)

Study contacts

• Principal investigator: Susanne S Hernes, M.D. Phd. — Sørlandet Sykehus HF, Universitetet i Bergen
• Study coordinator: Mona L Henriksen

Conditions: Mild Cognitive Impairment, computer-based cognitive training