Cognitive training for improving brain function in schizophrenia
Cognitive Remediation in Schizophrenia Patients: Study of the Efficacy and of the Role of Neuroplasticity in Two Different Approaches Based on "Top-down" and "Bottom-up" Mechanisms
This study tests two different brain training methods to see which one helps people with schizophrenia improve their thinking skills better while they are on medication.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 160 (estimated) |
| Ages | 18 Years to 59 Years |
| Sex | All |
| Sponsor | University of Chile Academic / other |
| Locations | 1 site (Santiago, RM) |
| Trial ID | NCT06482918 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of two cognitive remediation strategies for patients with schizophrenia: a 'top-down' approach focusing on higher-order cognitive processes and an alternative 'bottom-up' approach aimed at enhancing perceptual processing. The research evaluates both strategies in terms of their impact on neurocognitive performance and their relationship with changes in brain-derived neurotrophic factor (BDNF) levels. By comparing these approaches, the study seeks to identify which method is more effective in improving cognitive deficits associated with schizophrenia. The study involves clinically stable outpatients aged 18 to 59 who are currently receiving antipsychotic treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are clinically stable outpatients aged 18 to 59 with a diagnosis of schizophrenia who are currently on antipsychotic medication.
Not a fit: Patients with significant medical or neurological comorbidities or those actively using illegal drugs may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved cognitive functioning and quality of life for patients with schizophrenia.
How similar studies have performed: Previous studies have shown promising results with cognitive remediation strategies in schizophrenia, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of schizophrenia according to Diagnostic and Statistical Manual (DSM)-5 * Age between 18 and 59 years * Clinically stable outpatients * Current treatment with at least one antipsychotic medication Exclusion Criteria: * Significant medical or neurological comorbidity * Substance use disorder with illegal drugs in active use * Participation in a cognitive remediation program in the last 6 months
Where this trial is running
Santiago, RM
- Clinica Psiquiatrica Universitaria, Hospital Clinico de la Universidad de Chile — Santiago, Rm, Chile (Recruiting)
Study contacts
- Principal investigator: Rodrigo R. Nieto, MD PhD — University of Chile
- Study coordinator: Rodrigo R. Nieto, MD PhD
- Email: rnieto@uchile.cl
- Phone: +56229788601
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.