Cognitive training and enhanced treatment for youth at high risk of psychosis in Tunisia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to improve daily functioning in youth identified as clinically high risk for psychosis through two treatment approaches: a Cognitive Training (CT) program and an Enhanced Treatment as Usual (E-TAU) group. Participants will be randomly assigned to one of the two groups, with treatments lasting 12 weeks and involving both in-clinic and home sessions. The CT program includes engaging cognitive exercises designed to enhance thinking skills, while E-TAU provides standard care with additional group activities. Assessments of clinical symptoms and cognitive functioning will be conducted at baseline, mid-point, and conclusion of the treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Meets Comprehensive Assessment for At Risk Mental States (CAARMS) criteria for Clinical High Risk
* If under the age of 18, the subject has a parent or guardian who can sign consent forms
* Premorbid Intelligence Quotient not less than 70
* Sufficient fluency in Arabic, French, or English to avoid invalidating research measures
* Residence likely within commuting distance of Razi University Hospital

Exclusion Criteria:

* Evidence of known neurological disorder, e.g. epilepsy or significant head injury that could account for the CHR symptoms
* Evidence of significant and habitual alcohol or substance use in the 6 months prior to study entry
* Evidence that the clinical high-risk symptoms were substance-induced

Where it's running

• Razi University Hospital
  Tunis, Tunisia Recruiting

Study contacts

• Principal investigator: Joseph Ventura, Ph.D. — UCLA Department of Psychiatry & Biobehavioral Sciences
• Study coordinator: Joseph Ventura, Ph.D.
• Email: jventura@mednet.ucla.edu
• Phone: 310-245-2811

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.