Cognitive recovery after stroke with delirium
Cognitive Recovery After Post Stroke Delirium [RECOVER] a Longitudinal Pilot Proof of Concept Study in Stroke Patients With/without Delirium
This study is testing how cognitive abilities change over time in stroke patients who experience delirium compared to those who don’t.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | University Hospital Tuebingen Academic / other |
| Locations | 1 site (Tübingen) |
| Trial ID | NCT06680336 on ClinicalTrials.gov |
What this trial studies
This study investigates cognitive functioning in stroke patients, comparing those who experience post-stroke delirium to those who do not. It employs a longitudinal design with assessments conducted during the acute and post-acute phases of stroke, followed by a three-month follow-up. Cognitive functioning will be evaluated using a multi-component neuropsychological assessment and a task-based functional MRI that includes a modified working memory task.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 60 and older who have experienced an ischemic stroke within 96 hours of onset and have a National Institutes of Health Stroke Scale (NIHSS) score of 1 or higher.
Not a fit: Patients with pre-existing conditions such as dementia or psychiatric disorders, or those who have experienced delirium prior to enrollment, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of cognitive recovery in stroke patients, potentially leading to improved rehabilitation strategies.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in understanding cognitive recovery post-stroke, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 60 years * Ischemic stroke: Stroke Onset ≤ 96h, hospital admission ≤ 48h * NIHSS ≥ 1 * Informed consent by patient or legal guardian Exclusion Criteria: * Aphasia * Pre-existing conditions such as Dementia, psychiatric disorders (e.g., Depression, Schizophrenia) * MRI contraindication such as certain metal implants * Reduced consciousness, defined as Glasgow Coma Scale (GCS) ≤ 8 * Delirium onset before study enrollment
Where this trial is running
Tübingen
- Department of Neurology, University Hospital Tuebingen — Tübingen, Germany (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.