Cognitive and gut health interventions for alcohol users with HIV

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project evaluates two interventions aimed at improving cognition and gut health in individuals with HIV who consume alcohol. One intervention involves using a portable Transcutaneous Vagus Nerve Stimulator (tVNS) to stimulate the autonomic nervous system, potentially reducing inflammation and enhancing cognitive function. The second intervention is a probiotic supplement designed to restore healthy gut bacteria in participants experiencing dysbiosis. The study employs a hybrid trial design to assess the effectiveness of these interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 35-70 years
* English or Spanish speaking
* Alcohol users
* Cognitive impairment
* Current CD4\>350

Exclusion Criteria:

* Diagnosed major psychiatric illness
* Consumption of over 300 drinks in the past 30 days
* Recent opioid use
* Lifetime history of medically-assisted alcohol detoxification
* Inpatient or intensive treatment for addictive behaviors in the past 12 months
* MRI contraindications
* Current antibiotic treatment
* Current probiotic use
* Physical impairment precluding motor response or lying still.

Where it's running

• University of Miami
  Coral Gables, Florida, United States Recruiting

Study contacts

• Principal investigator: Eric Porges, PhD — University of Florida
• Study coordinator: Emily Carter
• Email: em.carter@phhp.ufl.edu
• Phone: 352-294-5837

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.