Cognitive and behavioral treatment for people with environmental intolerance

Effectiveness of a Cognitive and Behavioral Treatment Program in People With Idiopathic Environmental Intolerance (IEI)

Not applicable Interventional Institut National de la Santé Et de la Recherche Médicale, France · NCT05973214

This study is testing a new online therapy program to see if it can help people with environmental intolerance feel better and improve their quality of life.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment82 (estimated)
Ages18 Years and up
SexAll
SponsorInstitut National de la Santé Et de la Recherche Médicale, France Government
Locations1 site (Paris, Paris)
Trial IDNCT05973214 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness of a newly developed cognitive behavioral therapy (CBT) program for individuals suffering from Idiopathic Environmental Intolerance (IEI). The study employs a randomized controlled design, comparing outcomes between participants receiving the 8-week online CBT intervention and a wait-list control group. The program aims to address cognitive biases and negative expectations that may exacerbate symptoms attributed to environmental factors. The research seeks to enhance the quality of life for patients with IEI and contribute to the understanding of this complex condition.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older who have been diagnosed with Idiopathic Environmental Intolerance and experience significant symptoms.

Not a fit: Patients with severe mental health disorders, such as severe depression or substance use disorder, may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly improve the quality of life for patients suffering from Idiopathic Environmental Intolerance.

How similar studies have performed: While cognitive behavioral therapy has been effective in treating various psychological conditions, this specific application for Idiopathic Environmental Intolerance is novel and has not been extensively tested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Aged ≥18 years,
* Present a diagnosis of idiopathic environmental intolerance confirmed by the lead physician at the admission
* Be affiliated to a social security regime.
* Informed Consent

Exclusion Criteria:

* Severe depression, delusion disorder or substance use disorder
* No access to internet
* Non-French speakers
* Currently participating to another research on IEI
* Under an exclusion period for another study
* Benefiting from French state aid known as AME
* Deprivation of liberty by court or administrative order
* Hospitalized without consent
* Under protective measures
* Pregnancy and/or breastfeeding

Where this trial is running

Paris, Paris

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Idiopathic Environmental IntoleranceEnvironmental healthCognitive Behavioral TherapyFunctional DisorderSomatic Symptoms
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.