Clot analysis after ischemic stroke
Official title: Thrombus Analysis of Ischemic Stroke
Run by Seoul National University Hospital · NCT07043413 · Data updated 2026-11-12
This project will test whether analyzing clot tissue from people who had an endovascular thrombectomy for acute ischemic stroke can identify the stroke cause and help predict future vascular events.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Seoul National University Hospital Academic / other |
| Locations | 1 site (Seoul, Jong-ro Gu) |
| Status | Recruiting |
| Started | January 25, 2022 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2029 |
| Registry record updated | June 29, 2025 |
| Trial ID | NCT07043413 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with acute ischemic stroke who have undergone endovascular thrombectomy and can provide informed consent are the intended participants.
✕Probably not a fit
Patients who do not undergo thrombectomy, who cannot provide usable clot samples, or who are unable to attend follow-up visits are unlikely to benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Patients who undergo endovascular thrombectomy for acute ischemic stroke will be asked for consent to collect their removed clot material. Enrolled patients receive standard diagnostic workup and best medical treatment while clot samples undergo RNA expression profiling and histological characterization. Researchers will classify stroke mechanism (atherosclerotic, cardiac embolism, other, or unknown) using clinical data and clot features. Participants will be followed in outpatient clinic for up to two years to monitor recurrent stroke, death, and bleeding events while clot data are correlated with outcomes.
Why it matters
Potential benefit: If successful, clot analysis could help clinicians identify the underlying cause of a stroke more accurately and better predict who is at higher risk for future vascular events, allowing more targeted prevention.
How similar studies have gone: Previous histological and molecular studies of retrieved clots have shown promise linking clot features to stroke cause, but RNA-based classification and long-term prognostic use remain relatively novel and under active study.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients with acute ischemic stroke who had undergone endovascular thrombectomy Exclusion Criteria: \-
Where it's running
-
Seoul National University Hospital
Seoul, Jong-ro Gu, South Korea Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.